The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

This report details the invention of a method to enable syntheses of psychotrimine (1) and
the kapakahines F and B (2, 3) on a gram scale and in a minimum number of steps. …

The putative reductive activation chemistry of the diazoparaquinone antibiotics was modeled
with Bu 3 Sn−H and prekinamycin dimethyl ether along with prekinamycin itself. Reaction …

The syntheses of a bis indole and an indole salicylate with the required axial chirality for
diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp3 …

184 Background: Resistance to Androgen Receptor Signaling Inhibitors (ARSIs) in prostate
cancer occurs in almost all patients and is driven primarily by genomic alterations in AR and …

While specific cell signaling pathway inhibitors have yielded great success in oncology,
directly triggering cancer cell death is one of the great drug discovery challenges facing …

The increasing utilization of fluorine in drug design parallels advances in understanding the
physicochemical attributes of this element and an enhanced appreciation of how these …

Treatment of the representative diazoparaquinone prekinamycin dimethyl ether with Bu 3
SnH/AIBN in aromatic solvents furnishes moderate-to-good yields of formal aryl adducts …

Due to its unique C–C and C–H bonding properties, conformational preferences and relative
hydrophilicity, the cyclopropyl ring has been used as a synthetic building block in drug …

The development of a series of novel 7-azabenzofurans exhibiting pan-genotype inhibition
of HCV NS5B polymerase via binding to the primer grip site is presented. Many challenges, …