The use of primary hepatocytes is now well established for both studies of drug metabolism
and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for …

There is no doubt that diet is one of the main modifiable risk factors for many degenerative
diseases, including cancer. More than 30% of adult cancers can be prevented or delayed by …

Benzene and 13 potential metabolites were investigated for genotoxicity in Salmonella
typhimurium and V79 Chinese hamster cells. In the presence of NADPH-fortified hepatic …

The water insoluble residues of some carotenoid-rich fruits and vegetables, such as apricots,
oranges, brussels sprouts, carrots, yellow-red peppers, and tomatoes, were sequentially …

… Köttgen, KL Platt. Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol
in mice in vivo by fruits, vegetables, and flavonoids. Mutation Research/Genetic …

Chinese hamster lung fibroblasts, genetically engineered for the expression of rat
cytochrome P450 dependent monooxygenase 1A2 and rat sulfotransferase 1C1 (V79-rCYP1A2-…

Activities of various xenobiotic-metabolizing enzymes were determined in 18 cell lines.
Activities of cytochrome P450 reductase, microsomal epoxide hydrolase and glutathione …

Non-K-region1 dihydro diols of polycyclic aromatic hy-drocarbons (PAH), generated by the
epoxide hydrolase mediated hydration of metabolically formed arene oxides, play an …

The use of hepatocyte cultures is well established for the study of drug–drug interactions.
However, the major hindrance for the use of human hepatocyte cultures is that human …

Dibenzo[a,l]pyrene (DB[a,l]P) is an environmental contaminant and a very potent carcinogen.
DB[a,l]P exceeds the carcinogenic potency of both benzo[a]pyrene and 7, 12-dimethylbenz[…