Utilization of membrane vesicle preparations to study drug–ABC transporter interactions
…, M Jani, B Oosterhuis, K Herédi-Szabó… - Expert opinion on …, 2008 - Taylor & Francis
Background: The last 15 years have marked an expansion in our understanding of how ABC
transporters modulate the pharmacokinetic properties of drugs. Assays based on different …
transporters modulate the pharmacokinetic properties of drugs. Assays based on different …
BSEP inhibition–In vitro screens to assess cholestatic potential of drugs
…, E Ioja, Z Rajnai, M Jani, D Méhn, K Herédi-Szabó… - Toxicology in vitro, 2012 - Elsevier
Bile salt export pump (BSEP, ABC11) is a membrane protein that is localized in the cholesterol-rich
canalicular membrane of hepatocytes. Its function is to eliminate unconjugated and …
canalicular membrane of hepatocytes. Its function is to eliminate unconjugated and …
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk …
…, A Guo, I Hanna, K Herédi-Szabó, K Hillgren… - Drug metabolism and …, 2013 - ASPET
A P-glycoprotein (P-gp) IC 50 working group was established with 23 participating
pharmaceutical and contract research laboratories and one academic institution to assess …
pharmaceutical and contract research laboratories and one academic institution to assess …
Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance
…, O Ujhellyi, K Német, K Herédi-Szabó… - Annals of the …, 2009 - ard.bmj.com
… K Német2, … K Herédi-Szabó1, … I is the affinity of the inhibitor, IC 50 is the concentration of
the inhibitor which inhibits 50% of the transport, S is the concentration of the substrate and K m is …
the inhibitor which inhibits 50% of the transport, S is the concentration of the substrate and K m is …
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875 …
…, P Walker, K Herédi-Szabó, K Mogyorósi… - Toxicological …, 2019 - academic.oup.com
… In this study, experimental K i data were collected to further characterize inhibition of BSEP
and NTCP by TAK-875. Experimental details are provided in Supplementary material 1. …
and NTCP by TAK-875. Experimental details are provided in Supplementary material 1. …
A P-gp vesicular transport inhibition assay–Optimization and validation for drug–drug interaction testing
K Herédi-Szabó, JE Palm, TB Andersson, Á Pál… - European Journal of …, 2013 - Elsevier
… P-gp substrates inhibited transport of NMQ with estimated K i values of 250, 0.1 and 0.6 μM,
… P-gp-K and K-CTRL vesicles were derived from a cell line of human origin expressing P-gp (…
… P-gp-K and K-CTRL vesicles were derived from a cell line of human origin expressing P-gp (…
Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions
…, SP Chung, K Herédi-Szabó… - Drug Metabolism and …, 2013 - ASPET
In the 2012 Food and Drug Administration (FDA) draft guidance on drug-drug interactions (DDIs),
a new molecular entity that inhibits P-glycoprotein (P-gp) may need a clinical DDI study …
a new molecular entity that inhibits P-glycoprotein (P-gp) may need a clinical DDI study …
Quinidine as an ABCB1 probe for testing drug interactions at the blood–brain barrier: an in vitro in vivo correlation study
…, I Makai, E Kis, K Herédi-Szabó… - Journal of …, 2011 - journals.sagepub.com
This study provides evidence that quinidine can be used as a probe substrate for ABCB1 in
multiple experimental systems both in vitro and in vivo relevant to the blood–brain barrier (…
multiple experimental systems both in vitro and in vivo relevant to the blood–brain barrier (…
ABCG2 modulates chlorothiazide permeability in vitro–characterization of its interactions
…, S Bánsághi, F Erdő, I Sziráki, K Herédi-Szabó… - Drug metabolism and …, 2012 - Elsevier
… Our data show that chlorothiazide is transported by ABCG2 with a K m value of 334.6 μΜ
and does not interact with ABCB1 or ABCC2. The chlorothiazide–ABCG2 interaction results in …
and does not interact with ABCB1 or ABCC2. The chlorothiazide–ABCG2 interaction results in …
Comparison of 3 assay systems using a common probe substrate, calcein AM, for studying P-gp using a selected set of compounds
…, F Fülöp, P Krajcsi, K Herédi-Szabó - Journal of …, 2011 - journals.sagepub.com
The multidrug resistance protein 1 (MDR1) transporter is the most abundantly investigated
adenosine triphosphate (ATP)–Binding Cassette (ABC) transporter protein. Multiple assay …
adenosine triphosphate (ATP)–Binding Cassette (ABC) transporter protein. Multiple assay …