Studies on the structural and chromatographic properties of monolithic silica columns were
reviewed. Monolithic silica columns prepared from tetraalkoxysilane by a sol–gel method …

… As expected, l-Arg competitively inhibited l-NA transport with an apparent K i of 0.034 mM,
which compares well with the K m of 0.07 mM for high affinity l-Arg transport found in …

The pharmaceutical industry has been searching for an in vitro blood-brain barrier (BBB) model
that preserves in vivo transporter functions in CNS drug discovery and development. The …

… In discussion of the contributions of other specific interactions, separation factors (calculated
by dividing the k' value of a probe solute by the k' value of a standard solute under the same …

Sirtuin 1 (Sirt1), a NAD + -regulated deacetylase with numerous known positive effects on
cellular and whole-body metabolism, is expressed in the renal cortex and medulla. It is known …

Reduction of through-pore size and skeleton size of a monolithic silica column was attempted
to provide high separation efficiency in a short time. Monolithic silica columns were …

… theoretical plates for hexylbenzene having a k value of 1.5 in the pressure-driven LC with
split injection at 1.1 mm/s linear velocity. The k values obtained with the present monolithic …

Although tight‐junctions (TJs) at the blood–brain barrier (BBB) are important to prevent non‐specific
entry of compounds into the CNS, molecular mechanisms regulating TJ …

Two types of monolithic silica columns derivatized to form an ODS phase, one prepared in a
fused silica capillary (SR‐FS) and the other prepared in a mold and clad with an …

… realized for solutes with very low k values. The k values obtained with the present monolithic
… Due to the small retention factor (k), the effective plate number (N eff =N{k/(1+k)} 2 ) was …