Interleukin-18 regulates both Th1 and Th2 responses
K Nakanishi, T Yoshimoto, H Tsutsui… - Annual review of …, 2001 - annualreviews.org
Although interleukin-18 is structurally homologous to IL-1 and its receptor belongs to the IL-1R/Toll-like
receptor (TLR) superfamily, its function is quite different from that of IL-1. IL-18 is …
receptor (TLR) superfamily, its function is quite different from that of IL-1. IL-18 is …
On the adsorption of proteins on solid surfaces, a common but very complicated phenomenon
K Nakanishi, T Sakiyama, K Imamura - Journal of bioscience and …, 2001 - Elsevier
… K.: Adsorption of protein onto stainless steel particle surface and its desorption behavior. …
Lu, DR and Park, K.: Effect of surface hydrophobicity on the conformational changes of …
Lu, DR and Park, K.: Effect of surface hydrophobicity on the conformational changes of …
[HTML][HTML] Oxford classification of IgA nephropathy 2016: an update from the IgA nephropathy classification working group
…, K Joh, R Katafuchi, J Lv, K Matsuzaki, K Nakanishi… - Kidney international, 2017 - Elsevier
Since the Oxford Classification of IgA nephropathy (IgAN) was published in 2009, MEST
scores have been increasingly used in clinical practice. Further retrospective cohort studies …
scores have been increasingly used in clinical practice. Further retrospective cohort studies …
[HTML][HTML] Targeted disruption of the MyD88 gene results in loss of IL-1-and IL-18-mediated function
…, M Matsumoto, H Tsutsui, M Sakagami, K Nakanishi… - Immunity, 1998 - cell.com
MyD88, originally isolated as a myeloid differentiation primary response gene, is shown to
act as an adaptor in interleukin-1 (IL-1) signaling by interacting with both the IL-1 receptor …
act as an adaptor in interleukin-1 (IL-1) signaling by interacting with both the IL-1 receptor …
Essential role of Stat6 in IL-4 signalling
…, M Minami, S Kashiwamura, K Nakanishi… - Nature, 1996 - nature.com
INTERLEUKIN-4(IL-4) is a pleiotropic lymphokine which plays an important role in the
immune system 1 . IL-4 activates two distinct signalling pathways through tyrosine …
immune system 1 . IL-4 activates two distinct signalling pathways through tyrosine …
Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme
…, N Hayashi, K Higashino, H Okamura, K Nakanishi… - Science, 1997 - science.org
… This cleavage was specific with a catalytic efficiency (k cat /K m , where K m is the Michaelis
constant) of 1.4 × 10 7 M −1 s −1 (K m = 0.6 ± 0.1 μM; k cat = 8.6 ± 0.3 s −1 ) (15) and was …
constant) of 1.4 × 10 7 M −1 s −1 (K m = 0.6 ± 0.1 μM; k cat = 8.6 ± 0.3 s −1 ) (15) and was …
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
…, K Yui, T Tsujimura, DM Standley, K Nakanishi… - Nature …, 2010 - nature.com
Polarization of macrophages to M1 or M2 cells is important for mounting responses against
bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a …
bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a …
[BOOK][B] Circular dichroism: principles and applications
N Berova, K Nakanishi, RW Woody - 2000 - books.google.com
… For k electrons the number of terms is given by k![k!= 1× 2× 3...(k− 1)× k], so the Slater orbital
functions quickly become very large with a rising number of electrons. For such a simple …
functions quickly become very large with a rising number of electrons. For such a simple …
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production
…, H Okamura, S Akira, K Nakanishi - The Journal of …, 1998 - journals.aai.org
… The dissociation constant (K d ) and number of binding sites were calculated from … affinity
IL-18R (K d = 430 pM)/5500 low affinity IL-18R (K d = 31.4 nM) and 160 high affinity IL-18R (…
IL-18R (K d = 430 pM)/5500 low affinity IL-18R (K d = 31.4 nM) and 160 high affinity IL-18R (…
[PDF][PDF] Defective NK cell activity and Th1 response in IL-18–deficient mice
…, N Yoshida, T Kishimoto, H Okamura, K Nakanishi… - Immunity, 1998 - cell.com
IL-18 is a cytokine that is secreted from activated macrophages and induces IFNγ production.
To investigate the in vivo role of IL-18, we generated IL-18–deficient mice. In …
To investigate the in vivo role of IL-18, we generated IL-18–deficient mice. In …