… In general, K m orS 50 values for the substrates were 3 to 4 times lower for CYP3A4 than
for CYP3A5 or CYP3A7. For a more direct comparison of these P450 forms, clearance to the …

… Hydrolysis of prasugrel by hCE1 showed Michaelis-Menten kinetics yielding an apparent K
… At low concentrations, prasugrel hydrolysis by hCE2 yielded an apparent K s of 11.1 μM, an …

… The substrate was 4-nitrophenyl butyrate at a concentration near the K m or K s value for
the hydrolysis of 4NPB by each CES (20 μM for dCES1, 40 μM for cCES1 and dCES2, and 90 …

Definitive plasma protein binding (PB) studies in drug development are routinely conducted
with radiolabeled material, where the radiochemical purity limits quantitative PB …

A liquid chromatographic–tandem mass spectrometric (LC–MS–MS) assay was developed
and validated to quantitatively determine olanzapine (OLZ) concentrations in human blood. …

… , K Desino, L Heinle, K Ruterbories and S Doktor made substantial contributions to the
conception or design of the work, the interpretation of data for the work and the drafting or revising …

A liquid chromatography-tandem mass spectrometry method was developed to chromatographically
separate the four stereoisomers of the active metabolite of prasugrel, R-138727, in …

The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early
onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic …

A theoretical model has been developed for the separation of enantiomers of neutral species
by employing a combination of charged and neutral cyclodextrins. A neutral compound (…

Background: Understanding the distribution of the analyte between the cellular and
noncellular (plasma) components of the blood is important, especially in situations where dried …