Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies
K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016 - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …
personalized medicine. This review covers the principles, advantages, and drawbacks of …
Polymeric anticancer drugs with pH-controlled activation
K Ulbrich, V Šubr - Advanced drug delivery reviews, 2004 - Elsevier
Use of macromolecular water-soluble carriers of anti-cancer drugs represents a promising
approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for …
approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for …
Structural and chemical aspects of HPMA copolymers as drug carriers
K Ulbrich, V Šubr - Advanced drug delivery reviews, 2010 - Elsevier
Synthetic strategies and chemical and structural aspects of the synthesis of HPMA copolymer
conjugates with various drugs and other biologically active molecules are described and …
conjugates with various drugs and other biologically active molecules are described and …
Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)
K Ulbrich, T Hekmatara, E Herbert, J Kreuter - European Journal of …, 2009 - Elsevier
Human serum albumin (HSA) nanoparticles were manufactured by desolvation. Transferrin
or transferrin receptor monoclonal antibodies (OX26 or R17217) were covalently coupled to …
or transferrin receptor monoclonal antibodies (OX26 or R17217) were covalently coupled to …
Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues
…, J Wu, R Duncan, J Strohalm, K Ulbrich… - Japanese Journal of …, 1998 - Wiley Online Library
… ) copolymers of MW ranging from 4.5 K to 800 K were administered iv to mice … 50 K) showed
significantly increased tumor accumulation after 6 h, while the lower MW copolymers (<40 K) …
significantly increased tumor accumulation after 6 h, while the lower MW copolymers (<40 K) …
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier
…, H Maeda, M Brereton, J Strohalm, K Ulbrich… - European Journal of …, 1995 - Elsevier
The molecular weight-dependence of tumour capture of N-(2-hydroxypropyl)methacrylamide
(HPMA) copolymers (fractions of mw 22000–778000) was studied in vivo using …
(HPMA) copolymers (fractions of mw 22000–778000) was studied in vivo using …
Polymeric drugs based on conjugates of synthetic and natural macromolecules: I. Synthesis and physico-chemical characterisation
K Ulbrich, V Šubr, J Strohalm, D Plocova… - Journal of controlled …, 2000 - Elsevier
This paper describes the synthesis, physico-chemical characteristics and results of selected
biological tests of conjugates of antibodies or proteins with poly(HPMA) or with poly(HPMA) …
biological tests of conjugates of antibodies or proteins with poly(HPMA) or with poly(HPMA) …
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
KD Fisher, Y Stallwood, NK Green, K Ulbrich… - Gene therapy, 2001 - nature.com
Adenovirus is a widely used vector for cancer gene therapy because of its high infection
efficiency and capacity for transgene expression in both dividing and nondividing cells. However…
efficiency and capacity for transgene expression in both dividing and nondividing cells. However…
Polymeric micellar pH-sensitive drug delivery system for doxorubicin
M Hrubý, Č Koňák, K Ulbrich - Journal of Controlled Release, 2005 - Elsevier
A novel polymeric micellar pH-sensitive system for delivery of doxorubicin (DOX) is described.
Polymeric micelles were prepared by self-assembly of amphiphilic diblock copolymers in …
Polymeric micelles were prepared by self-assembly of amphiphilic diblock copolymers in …
[HTML][HTML] Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
Gene therapy for systemic diseases requires intravenous administration, but existing vectors
are not suitable for systemic delivery, often showing rapid elimination from the bloodstream …
are not suitable for systemic delivery, often showing rapid elimination from the bloodstream …