The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

J Liu, M Gao, J He, K Wu, S Lin, L Jin, Y Chen, H Liu… - Nature, 2021 - nature.com
The RNA modification N 6 -methyladenosine (m 6 A) has critical roles in many biological
processes 1 , 2 . However, the function of m 6 A in the early phase of mammalian development …

[HTML][HTML] Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells

…, J Zhou, LI Sun, C Chang, Y Li, H Liu, K Wu… - Nature …, 2019 - nature.com
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst
TEs are increasingly recognized for their important biological functions, they are a potential …

[PDF][PDF] Resolving cell fate decisions during somatic cell reprogramming by single-cell RNA-Seq

L Guo, L Lin, X Wang, M Gao, S Cao, Y Mai, F Wu… - Molecular cell, 2019 - cell.com
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs), which is a
highly heterogeneous process. Here we report the cell fate continuum during somatic cell …

[PDF][PDF] YTHDF2/3 are required for somatic reprogramming through different RNA deadenylation pathways

J Liu, M Gao, S Xu, Y Chen, K Wu, H Liu, J Wang… - Cell Reports, 2020 - cell.com
N 6 -methyladenosine (m 6 A), the most abundant reversible modification on eukaryote
messenger RNA, is recognized by a series of readers, including the YT521-B homology domain …

[PDF][PDF] SETDB1-mediated cell fate transition between 2C-like and pluripotent states

K Wu, HE Liu, Y Wang, J He, S Xu, Y Chen, J Kuang… - Cell reports, 2020 - cell.com
Known as a histone H3K9 methyltransferase, SETDB1 is essential for embryonic development
and pluripotent inner cell mass (ICM) establishment. However, its function in pluripotency …

Moment magnitudes of two large Turkish earthquakes on February 6, 2023 from long-period coda

X Jiang, X Song, T Li, K Wu - Earthquake Science, 2023 - equsci.org.cn
Two large earthquakes (an earthquake doublet) occurred in south-central Turkey on February
6, 2023, causing massive damages and casualties. The magnitudes and the relative sizes …

BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling

S Yu, C Zhou, S Cao, J He, B Cai, K Wu, Y Qin… - Nature cell …, 2020 - nature.com
BMP4 regulates a plethora of developmental processes, including the dorsal–ventral axis
and neural patterning. Here, we report that BMP4 reconfigures the nuclear architecture during …

Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation

FL Liu, K Wu, J Sun, Z Duan, X Quan… - National Science …, 2021 - academic.oup.com
About every 26 months, the distance between Earth and Mars reaches a minimum, and that
is the best time window for Mars exploration from Earth. In July 2020, three spacecraft started …

Proteomic changes in chicken primary hepatocytes exposed to T‐2 toxin are associated with oxidative stress and mitochondrial enhancement

P Mu, M Xu, L Zhang, K Wu, J Wu, J Jiang, Q Chen… - …, 2013 - Wiley Online Library
T ‐2 toxin is a mycotoxin that is toxic to plants, animals, and humans. However, its molecular
mechanism remains unclear, especially in chickens. In this study, using 2 D electrophoresis …

Dissipation behavior, residue distribution and risk assessment of three fungicides in pears

Q Fang, R Wu, G Hu, A Lai, K Wu… - Journal of the …, 2020 - Wiley Online Library
BACKGROUND Fungicides are often applied to pears before they are kept in storage facilities.
The scientific application of pesticides can reduce unnecessary exposure, which in turn …