Identification and quantification of daidzein-7-glucuronide-4′-sulfate, genistein-7-glucuronide-4′-sulfate and genistein-4′, 7-diglucuronide as major metabolites in …

K Hosoda, T Furuta, A Yokokawa, K Ishii - Analytical and bioanalytical …, 2010 - Springer
Much attention has been paid to the metabolism and disposition of isoflavones daidzein (Dein)
and genistein (Gein) with regard to the prevention of several hormone-dependent …

Metabolism and disposition of isoflavone conjugated metabolites in humans after ingestion of kinako

K Hosoda, T Furuta, K Ishii - Drug Metabolism and Disposition, 2011 - ASPET
Isoflavone aglycones daidzein (Dein) and genistein (Gein) are present primarily as
glucuronides and sulfates in human plasma; however, very little is known about the plasma …

Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and …

K Hosoda, T Furuta, A Yokokawa, K Ogura… - Drug Metabolism and …, 2008 - ASPET
The roles of isoflavones in the prevention of several hormone-dependent cancers and
osteoporosis are of great interest. Despite many pharmacokinetics studies of the isoflavones, the …

Simultaneous determination of glucuronic acid and sulfuric acid conjugated metabolites of daidzein and genistein in human plasma by high-performance liquid …

K Hosoda, T Furuta, K Ishii - Journal of Chromatography B, 2010 - Elsevier
Isoflavone aglycones daidzein (Dein) and genistein (Gein) are mainly present as glucuronides
and sulfates in human plasma, and small amounts of the intact aglycones are also …

Intraindividual and interindividual variabilities in endogenous cortisol 6β-hydroxylation clearance as an index for in vivo CYP3A phenotyping in humans

H Shibasaki, K Hosoda, M Goto, A Suzuki… - Drug Metabolism and …, 2013 - ASPET
This study was designed to evaluate the in vivo activity of cytochrome P450 3A (CYP3A) in
49 healthy Japanese subjects aged 22–58 years using endogenous cortisol 6β-hydroxylation …

Identification of equol‐7‐glucuronide‐4′‐sulfate, monoglucuronides and monosulfates in human plasma of 2 equol producers after administration of kinako by LC …

A Obara, M Kinoshita, K Hosoda… - Pharmacology …, 2019 - Wiley Online Library
Equol is a product formed during the biotransformation of the naturally occurring isoflavone
daidzein by intestinal bacteria. The role of equol in the prevention of several hormone‐…

Isoflavones: high-performance liquid chromatographic analysis of glucuronic acid-and sulfuric acid-conjugated metabolites of daidzein and genistein in human …

K Ishii, K Hosoda, T Furuta - 2012 - books.rsc.org
Several methods for the determination of glucuronic acid-and/or sulfuric acid-conjugated
metabolites of daidzein and genistein in human plasma have been reported. The methods can …

TAKASHIFURUTAb

K ISHII, K HOSODA - Isoflavones: Chemistry, Analysis, Function …, 2012 - books.google.com
The effect on human health of the isoflavones daidzein and genistein has been widely
studied. These isoflavones are thought to play a role in the prevention of various hormone-…

Intra-and Inter-individual Variabilities in Endogenous Cortisol 6β-hydroxylation Clearance as an Index for in Vivo CYP3A Phenotyping in Humans

H Shibasaki, K Hosoda, M Goto, A Suzuki… - Drug Metabolism and …, 2012 - ASPET
The present study was designed to evaluate the in vivo activity of cytochrome P450 3A (CYP3A)
in 49 healthy Japanese subjects aged 22-58 years using endogenous cortisol 6β-…

[CITATION][C] Plasma profiling of intact isoflavone metabolites by HPLC and mass spectrometric identification of flavone glycosides, daidzin and genistin in human …

K Hosoda, T Furuta, A Yokokawa, K Ogura… - Drug Metabolism and …, 2008 - ASPET
The roles of isoflavones in the prevention of several hormone-dependent cancers and
osteoporosis are of great interest. Despite many pharmacokinetics studies of the isoflavones, …