Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies
K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016 - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …
personalized medicine. This review covers the principles, advantages, and drawbacks of …
Polymeric anticancer drugs with pH-controlled activation
K Ulbrich, V Šubr - Advanced drug delivery reviews, 2004 - Elsevier
Use of macromolecular water-soluble carriers of anti-cancer drugs represents a promising
approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for …
approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for …
Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues
…, J Wu, R Duncan, J Strohalm, K Ulbrich… - Japanese Journal of …, 1998 - Wiley Online Library
The objective of this study was to investigate the molecular weight (MW) and time‐dependence
of the phenomenon termed “the enhanced permeability and retention”(EPR) effect in …
of the phenomenon termed “the enhanced permeability and retention”(EPR) effect in …
Polymeric micellar pH-sensitive drug delivery system for doxorubicin
M Hrubý, Č Koňák, K Ulbrich - Journal of Controlled Release, 2005 - Elsevier
A novel polymeric micellar pH-sensitive system for delivery of doxorubicin (DOX) is described.
Polymeric micelles were prepared by self-assembly of amphiphilic diblock copolymers in …
Polymeric micelles were prepared by self-assembly of amphiphilic diblock copolymers in …
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties
T Etrych, M Jelı́nková, B Řı́hová, K Ulbrich - Journal of Controlled Release, 2001 - Elsevier
In this paper we describe the synthesis, physico-chemical characteristics and results of tests
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin (…
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin (…
Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers
MA Wolfert, EH Schacht, V Toncheva, K Ulbrich… - Human gene …, 1996 - liebertpub.com
Cationic polymers can self-assemble with DNA to form polyelectrolyte complexes capable
of gene delivery, although biocompatibility of the complexes is generally limited. Here we …
of gene delivery, although biocompatibility of the complexes is generally limited. Here we …
[HTML][HTML] Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
Gene therapy for systemic diseases requires intravenous administration, but existing vectors
are not suitable for systemic delivery, often showing rapid elimination from the bloodstream …
are not suitable for systemic delivery, often showing rapid elimination from the bloodstream …
Passive versus active tumor targeting using RGD-and NGR-modified polymeric nanomedicines
…, B Hermanns-Sachweh, M Pechar, K Ulbrich… - Nano …, 2014 - ACS Publications
Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-related
surface receptors are key features of tumor blood vessels. As a consequence, EPR-…
surface receptors are key features of tumor blood vessels. As a consequence, EPR-…
Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA
…, S Smart, J Strohalm, K Ulbrich - Bioconjugate …, 1999 - ACS Publications
Cationic polymer/DNA complexes are widely used for gene delivery, although the influence
of the cationic polymer on the biophysical properties of the resulting complex is poorly …
of the cationic polymer on the biophysical properties of the resulting complex is poorly …
Novel vectors for gene delivery formed by self-assembly of DNA with poly (L-lysine) grafted with hydrophilic polymers
…, MA Wolfert, PR Dash, D Oupicky, K Ulbrich… - … et Biophysica Acta (BBA …, 1998 - Elsevier
Complexes formed between DNA and cationic polymers are attracting increasing attention as
novel synthetic vectors for delivery of genes. We are trying to improve biological properties …
novel synthetic vectors for delivery of genes. We are trying to improve biological properties …