Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies

K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016 - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …

Polymeric anticancer drugs with pH-controlled activation

K Ulbrich, V Šubr - Advanced drug delivery reviews, 2004 - Elsevier
Use of macromolecular water-soluble carriers of anti-cancer drugs represents a promising
approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for …

Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues

…, J Wu, R Duncan, J Strohalm, K Ulbrich… - Japanese Journal of …, 1998 - Wiley Online Library
The objective of this study was to investigate the molecular weight (MW) and time‐dependence
of the phenomenon termed “the enhanced permeability and retention”(EPR) effect in …

Polymeric micellar pH-sensitive drug delivery system for doxorubicin

M Hrubý, Č Koňák, K Ulbrich - Journal of Controlled Release, 2005 - Elsevier
A novel polymeric micellar pH-sensitive system for delivery of doxorubicin (DOX) is described.
Polymeric micelles were prepared by self-assembly of amphiphilic diblock copolymers in …

New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties

T Etrych, M Jelı́nková, B Řı́hová, K Ulbrich - Journal of Controlled Release, 2001 - Elsevier
In this paper we describe the synthesis, physico-chemical characteristics and results of tests
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin (…

Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers

MA Wolfert, EH Schacht, V Toncheva, K Ulbrich… - Human gene …, 1996 - liebertpub.com
Cationic polymers can self-assemble with DNA to form polyelectrolyte complexes capable
of gene delivery, although biocompatibility of the complexes is generally limited. Here we …

[HTML][HTML] Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation

D Oupicky, M Ogris, KA Howard, PR Dash, K Ulbrich… - Molecular Therapy, 2002 - cell.com
Gene therapy for systemic diseases requires intravenous administration, but existing vectors
are not suitable for systemic delivery, often showing rapid elimination from the bloodstream …

Passive versus active tumor targeting using RGD-and NGR-modified polymeric nanomedicines

…, B Hermanns-Sachweh, M Pechar, K Ulbrich… - Nano …, 2014 - ACS Publications
Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-related
surface receptors are key features of tumor blood vessels. As a consequence, EPR-…

Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA

…, S Smart, J Strohalm, K Ulbrich - Bioconjugate …, 1999 - ACS Publications
Cationic polymer/DNA complexes are widely used for gene delivery, although the influence
of the cationic polymer on the biophysical properties of the resulting complex is poorly …

Novel vectors for gene delivery formed by self-assembly of DNA with poly (L-lysine) grafted with hydrophilic polymers

…, MA Wolfert, PR Dash, D Oupicky, K Ulbrich… - … et Biophysica Acta (BBA …, 1998 - Elsevier
Complexes formed between DNA and cationic polymers are attracting increasing attention as
novel synthetic vectors for delivery of genes. We are trying to improve biological properties …