Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

A paucity of versatile small animal models of hepatitis B virus (HBV) and hepatitis C virus (HCV)
infection has been an impediment to both furthering understanding of virus biology and …

Many metabolic liver disorders are refractory to drug therapy and require orthotopic liver
transplantation. Here we demonstrate a new strategy, which we call metabolic pathway …

Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated
the generation of new mouse models. Nonetheless, many metabolic disease models still …

Sacrificial templates for patterning perfusable vascular networks in engineered tissues have
been constrained in architectural complexity, owing to the limitations of extrusion-based 3D …

Human embryonic stem (hES) cells show an atypical cell-cycle regulation characterized by
a high proliferation rate and a short G1 phase [1,2]. In fact, a shortened G1 phase might …

Only one out of 10 drugs in development passes clinical trials. Many fail because experimental
animal models poorly predict human xenobiotic metabolism. Human liver chimeric mice …

We report the successful transplantation of human hepatocytes in immunodeficient,
fumarylacetoacetate hydrolase-deficient (fah −/− ) mice. Engraftment occurs over the entire liver …

Mice xenotransplanted with human cells and/or expressing human gene products (also known
as “humanized mice”) recapitulate the human evolutionary specialization and diversity of …

Hepatic cancer is one of the most lethal cancers worldwide. Here, we report that the expression
of Ca 2+ /calmodulin‐dependent protein kinase kinase 2 (CaMKK2) is significantly up‐…