The configuration of the 17-hydroxy group variably influences the glucuronidation of β-estradiol and epiestradiol by human UDP-glucuronosyltransferases
K Itäaho, PI Mackenzie, S Ikushiro, JO Miners… - Drug Metabolism and …, 2008 - ASPET
The glucuronidation of 17β-estradiol (β-estradiol) and 17α-estradiol (epiestradiol) was studied
to elucidate how the orientation of the 17-OH group affects conjugation at the 3-OH or the …
to elucidate how the orientation of the 17-OH group affects conjugation at the 3-OH or the …
Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10
K Itäaho, P Uutela, R Kostiainen… - Drug metabolism and …, 2009 - ASPET
The purpose of this work was to identify human UDP-glucuronosyltransferases (UGTs)
capable of glucuronidating dopamine. Using a sensitive liquid chromatography-tandem mass …
capable of glucuronidating dopamine. Using a sensitive liquid chromatography-tandem mass …
Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood …
K Itäaho, S Alakurtti, J Yli-Kauhaluoma… - Biochemical …, 2007 - Elsevier
SULT1A3 is an enzyme that catalyzes the sulfonation of many endogenous and exogenous
phenols and catechols. The most important endogenous substrate is dopamine (DA), which …
phenols and catechols. The most important endogenous substrate is dopamine (DA), which …
How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and …
K Itäaho, L Laakkonen, M Finel - Drug metabolism and disposition, 2010 - ASPET
The amino acid sequences of the human UDP-glucuronosyltransferases (UGTs) 1A9 and
1A10 are 93% identical, yet there are large differences in their activity and substrate selectivity. …
1A10 are 93% identical, yet there are large differences in their activity and substrate selectivity. …
[HTML][HTML] Understanding Human Drug Conjugating Enzymes: Regio-and Stereoselectivity in Sulfotransferase 1A3 and the UDP-glucuronosyltransferases
K Itäaho - 2011 - helda.helsinki.fi
Sulfotransferases (SULTs) and UDP-glucuronosyltransferases (UGTs) are important
detoxification enzymes and they contribute to bioavailability and elimination of many drugs. …
detoxification enzymes and they contribute to bioavailability and elimination of many drugs. …
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan
A Alonen, M Finel, R Kostiainen - Biochemical pharmacology, 2008 - Elsevier
Losartan, candesartan, and zolarsartan are AT 1 receptor antagonists that inhibit the effect
of angiotensin II. We have examined their glucuronidation by liver microsomes from several …
of angiotensin II. We have examined their glucuronidation by liver microsomes from several …
Analysis of intact glucuronides and sulfates of serotonin, dopamine, and their phase I metabolites in rat brain microdialysates by liquid chromatography− tandem mass …
P Uutela, R Reinila, K Harju, P Piepponen… - Analytical …, 2009 - ACS Publications
… We are grateful to Minna Baarman for her technical assistance and to Anna Alonen, Katriina
Itäaho, and Taina Sten for their helpful discussions. This study was financially supported by …
Itäaho, and Taina Sten for their helpful discussions. This study was financially supported by …
[PDF][PDF] Dopamine is a low affinity and high specificity substrate for the human UDP-glucuronosyltransferase 1A10
M Finel - 2008 - Citeseer
… specificity substrate for the human UDP- glucuronosyltransferase 1A10* Katriina Itäaho, Mi
… We have previously analyzed dopamine sulfonation by SULT1A3 (Itäaho et al., 2007) and in …
… We have previously analyzed dopamine sulfonation by SULT1A3 (Itäaho et al., 2007) and in …
Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol
P Lehtonen, T Sten, O Aitio, M Kurkela… - European journal of …, 2010 - Elsevier
O-Desmethyltramadol, the active metabolite of analgesic tramadol, is metabolised through
glucuronidation. The present study was conducted to identify the human UDP-…
glucuronidation. The present study was conducted to identify the human UDP-…
[PDF][PDF] Stereoselectivity of the Human UDP-glucuronosyltransferases: Studies on Androgens and Propranolol Glucuronidation
T Sten - 2010 - helda.helsinki.fi
Metabolic reactions are divided into functionalization and conjugation reactions. Uridine
diphosphoglucuronosyltransferases (UGTs) are an important group of conjugative enzymes that …
diphosphoglucuronosyltransferases (UGTs) are an important group of conjugative enzymes that …