Purpose The clinical efficacy of tamoxifen is suspected to be influenced by the activity of
drug-metabolizing enzymes and transporters involved in the formation, metabolism, and …

The coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has rapidly
expanded to a global pandemic. However, numbers of infected cases, deaths, and mortality …

To control and prevent the current COVID-19 pandemic, the development of novel vaccines
is an emergent issue. In addition, we need to develop tools that can measure/monitor T-cell …

The clinical outcomes of breast cancer patients treated with tamoxifen may be influenced by
the activity of cytochrome P450 2D6 (CYP2D6) enzyme because tamixifen is metabolized by …

Tamoxifen has been widely used for the prevention of recurrence in patients with hormone
receptor-positive breast cancer. Tamoxifen requires metabolic activation by cytochrome P450 …

With the significant advances in cancer genomics using next-generation sequencing
technologies, genomic and molecular profiling-based precision medicine is used as a part of …

We reported previously that subjects homozygous for the cytochrome P450 2A6 ( CYP2A6 )
* 4 have a lower risk of lung cancer. The purpose of this study was to clarify whether or not …

An 80‐year‐old man, who developed multiple lymph node and skin metastasis of malignant
melanoma, received nivolumab monotherapy. Two weeks after the first dose, he …

Immune checkpoint blockade against programmed cell death 1 (PD-1) and its ligand PD-L1
often induces durable tumor responses in various cancers, including non–small cell lung …

We developed a rapid single nucleotide polymorphism (SNP) detection system named smart
amplification process version 2 (SMAP 2). Because DNA amplification only occurred with a …