The human absorption, distribution, metabolism, and excretion (hADME) study is the
cornerstone of the clinical pharmacology package for small molecule drugs, providing …

Cathepsin S (Cat S) plays an important role in many pathological conditions, including
abdominal aortic aneurysm (AAA). Inhibition of Cat S may provide a new treatment for AAA. To …

The first total synthesis of streptonigrone (1) is detailed and is based on the implementation
of a room-temperature, inverse electron demand Diels-Alder reaction of the A-sulfonyl-1-aza-…

The disposition and metabolism of isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate
(LY2452473; a selective androgen receptor …

Two 2-aminoimidazole-based inhibitors, LY3031207 (1) and LY3023703 (2), of the microsomal
prostaglandin E synthase-1 (mPGES-1) enzyme were found to cause drug-induced liver …

LY2090314 (3-[9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-1H-pyrrole-2,5-dione)
is an intravenous glycogen …

A review of the use of microdoses and isotopic microtracers for clinical intravenous
pharmacokinetic (iv PK) data provision is presented. The extent of application of the varied …

Alkylation of the enolate la obtained from the (fi)-camphor imine of fert-butyl glycinate with a
variety of alkylating agents gives products whose trendsin diastereomeric excesses appear …

The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early
onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic …

Abemaciclib is a selective and potent small-molecule inhibitor of cyclin-dependent kinases
4 and 6 (CDK4 and CDK6) being investigated for treatment of refractory hormone-receptor …