pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1
…, CJ Rotter, J Chupka, KM Whalen… - Molecular …, 2011 - ACS Publications
The human organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) is ubiquitously
expressed and may play an important role in the disposition of xenobiotics. The present …
expressed and may play an important role in the disposition of xenobiotics. The present …
High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models
…, J Umland, M West, KM Whalen… - Current drug …, 2008 - ingentaconnect.com
Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important
role in drug discovery and development and several reliable in vitro ADME models are …
role in drug discovery and development and several reliable in vitro ADME models are …
A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening
JS Janiszewski, KJ Rogers, KM Whalen… - Analytical …, 2001 - ACS Publications
HPLC/MS is a linear technique characterized by serial injection and analysis of individual
samples. Parallel-format high-throughput screens for druglike properties present a significant …
samples. Parallel-format high-throughput screens for druglike properties present a significant …
In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation
…, HM Jones, HA Barton, S Kempshall, KM Whalen… - Drug Metabolism and …, 2012 - ASPET
To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a model
to characterize transport kinetics for in vivo pharmacokinetic prediction, the expression of …
to characterize transport kinetics for in vivo pharmacokinetic prediction, the expression of …
Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes
Sandwich-cultured human hepatocytes (SCHH) have been widely used for in vitro assessments
of biliary clearance. However, the modulation of metabolism enzymes has not been fully …
of biliary clearance. However, the modulation of metabolism enzymes has not been fully …
AutoScan: an automated workstation for rapid determination of mass and tandem mass spectrometry conditions for quantitative bioanalytical mass spectrometry
KM Whalen, KJ Rogers, MJ Cole… - … in Mass Spectrometry, 2000 - Wiley Online Library
An automated flow injection analysis (FIA) mass spectrometry system (AutoScan) was
developed to allow rapid unattended determination of optimal conditions during mass (ms) and …
developed to allow rapid unattended determination of optimal conditions during mass (ms) and …
[PDF][PDF] Autumn migration of Northern Saw-whet Owls (Aegolius acadicus) in the middle Atlantic and northeastern United States: what observations from 1995 suggest
DF Brinker, KE Duffy, DM Whalen, BD Watts… - UNITED STATES …, 1997 - fs.usda.gov
[PDF][PDF] Accelerated Communication Differential Modulation of Cytochrome P450 Activity and the Effect of 1-Aminobenzotriazole on Hepatic Transport in Sandwich …
…, R Walsky, H Zhang, Y Bi, KM Whalen… - DRUG METABOLISM …, 2012 - researchgate.net
Sandwich-cultured human hepatocytes (SCHH) have been widely used for in vitro assessments
of biliary clearance. However, the modulation of metabolism enzymes has not been fully …
of biliary clearance. However, the modulation of metabolism enzymes has not been fully …
Applications of new techniques in tandem mass spectrometry.
KM Whalen - 1997 - elibrary.ru
Degree: M. Sc. DegreeYear: 1996 Institute: Dalhousie University (Canada) Tandem mass
spectrometry is a technique which is continually being developed. New ideas aimed at …
spectrometry is a technique which is continually being developed. New ideas aimed at …
[BOOK][B] MARIAN COLLEGE, INDIANAPOLIS, INDIANA: THE FIRST QUARTER-CENTURY, 1937-1962.
MG Whalen - 1966 - search.proquest.com
… In the thirty years before her election to the office of Mother General, Sister M# Clarissa
was in direct contact with the earlier educators of the congregation who exerted every effort in …
was in direct contact with the earlier educators of the congregation who exerted every effort in …