Background Cardiac implantable electronic device (CIED) infection is associated with morbidity
and mortality. Objectives To determine the incidence and risk factors for CIED infection, …

PURPOSE: To explore the association of angiographic nonperfusion in focal and diffuse
recalcitrant diabetic macular edema (DME) in diabetic retinopathy (DR). DESIGN: A …

The mechanism underlying subcutaneous absorption of macromolecules and factors that
can influence this process were studied in rats using PEGylated erythropoietins (EPOs) as …

Purpose To characterize the pharmacokinetics of simvastatin (SV) and simvastatin acid (SVA),
a lactone–acid pair known to undergo reversible metabolism, and to better understand …

Enterohepatic recirculation (EHR) occurs via biliary excretion and intestinal reabsorption of
a drug. Drug recycling through EHR can lead to a change in pharmacokinetic (PK) properties…

It is postulated that elevated tissue concentrations of cortisol may be associated with the
development of metabolic syndrome, obesity, and type 2 diabetes. The 11β-hydroxysteroid …

Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL-C levels by
binding to cell surface LDL-receptor protein (LDLR) and is an important therapeutic target for …

Compound I [3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one]
is a potent inhibitor of human kinase insert domain-containing receptor (KDR kinase), …

Purpose: In this study we have 2 main objectives: i) to study the peripheral angiographic
features of patients with recalcitrant diabetic macular edema (DME) and peripheral retinal …

Background: Infection following device implantation is associated with morbidity and mortality.
Although several risk factors have been identified, the quantifiable risk in any patient (pt) …