[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
…, HG Holzhuetter, JB Houston, J Hrach, K Ito… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
Database analyses for the prediction of in vivo drug–drug interactions from in vitro data
K Ito, HS Brown, JB Houston - British journal of clinical …, 2004 - Wiley Online Library
Aims In theory, the magnitude of an in vivo drug–drug interaction arising from the inhibition
of metabolic clearance can be predicted using the ratio of inhibitor concentration ([I]) to …
of metabolic clearance can be predicted using the ratio of inhibitor concentration ([I]) to …
Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches
K Ito, JB Houston - Pharmaceutical research, 2005 - Springer
No Heading Purpose. The aim of this study is to compare the accuracy of five methods for
predicting in vivo intrinsic clearance (CL int ) and seven for predicting hepatic clearance (CL h …
predicting in vivo intrinsic clearance (CL int ) and seven for predicting hepatic clearance (CL h …
Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes
K Ito, JB Houston - Pharmaceutical research, 2004 - Springer
Purpose. To compare three liver models (well-stirred, parallel tube, and dispersion) for the
prediction of in vivo intrinsic clearance (CL int ), hepatic clearance (CL h ), and hepatic …
prediction of in vivo intrinsic clearance (CL int ), hepatic clearance (CL h ), and hepatic …
CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions
A Galetin, K Ito, D Hallifax, JB Houston - Journal of Pharmacology and …, 2005 - ASPET
The complexity of in vitro kinetic phenomena observed for CYP3A4 substrates (homo- or
heterotropic cooperativity) confounds the prediction of drug-drug interactions, and an …
heterotropic cooperativity) confounds the prediction of drug-drug interactions, and an …
[HTML][HTML] Anti-obesity and anti-diabetic effects of acacia polyphenol in obese diabetic KKAy mice fed high-fat diet
N Ikarashi, T Toda, T Okaniwa, K Ito, W Ochiai… - Evidence-Based …, 2011 - hindawi.com
Acacia polyphenol (AP) extracted from the bark of the black wattle tree (Acacia meansii) is
rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol. The present …
rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol. The present …
Prediction of in vivo drug–drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant
HS Brown, K Ito, A Galetin… - British journal of clinical …, 2005 - Wiley Online Library
Aims Success of the quantitative prediction of drug–drug interactions via inhibition of CYP‐mediated
metabolism from the inhibitor concentration at the enzyme active site ([I]) and the in …
metabolism from the inhibitor concentration at the enzyme active site ([I]) and the in …
Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes
K Ito, K Ogihara, S Kanamitsu, T Itoh - Drug Metabolism and Disposition, 2003 - ASPET
Clinical studies have revealed that plasma concentrations of midazolam after oral administration
are greatly increased by coadministration of erythromycin and clarithromycin, whereas …
are greatly increased by coadministration of erythromycin and clarithromycin, whereas …
[HTML][HTML] Classification of drugs for evaluating drug interaction in drug development and clinical management
During new drug development, clinical drug interaction studies are carried out in accordance
with the mechanism of potential drug interactions evaluated by in vitro studies. The …
with the mechanism of potential drug interactions evaluated by in vitro studies. The …
Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm
K Ito, D Hallifax, RS Obach, JB Houston - Drug Metabolism and Disposition, 2005 - ASPET
The success of in vitro derived K i values for predicting drug-drug interactions in vivo has
been mixed. For example, the use of hepatic input concentration of inhibitor has resolved the …
been mixed. For example, the use of hepatic input concentration of inhibitor has resolved the …