[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

…, HG Holzhuetter, JB Houston, J Hrach, K Ito… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

Database analyses for the prediction of in vivo drug–drug interactions from in vitro data

K Ito, HS Brown, JB Houston - British journal of clinical …, 2004 - Wiley Online Library
Aims In theory, the magnitude of an in vivo drug–drug interaction arising from the inhibition
of metabolic clearance can be predicted using the ratio of inhibitor concentration ([I]) to …

Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

K Ito, JB Houston - Pharmaceutical research, 2005 - Springer
No Heading Purpose. The aim of this study is to compare the accuracy of five methods for
predicting in vivo intrinsic clearance (CL int ) and seven for predicting hepatic clearance (CL h …

Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes

K Ito, JB Houston - Pharmaceutical research, 2004 - Springer
Purpose. To compare three liver models (well-stirred, parallel tube, and dispersion) for the
prediction of in vivo intrinsic clearance (CL int ), hepatic clearance (CL h ), and hepatic …

CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

A Galetin, K Ito, D Hallifax, JB Houston - Journal of Pharmacology and …, 2005 - ASPET
The complexity of in vitro kinetic phenomena observed for CYP3A4 substrates (homo- or
heterotropic cooperativity) confounds the prediction of drug-drug interactions, and an …

[HTML][HTML] Anti-obesity and anti-diabetic effects of acacia polyphenol in obese diabetic KKAy mice fed high-fat diet

N Ikarashi, T Toda, T Okaniwa, K Ito, W Ochiai… - Evidence-Based …, 2011 - hindawi.com
Acacia polyphenol (AP) extracted from the bark of the black wattle tree (Acacia meansii) is
rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol. The present …

Prediction of in vivo drug–drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

HS Brown, K Ito, A Galetin… - British journal of clinical …, 2005 - Wiley Online Library
Aims Success of the quantitative prediction of drug–drug interactions via inhibition of CYP‐mediated
metabolism from the inhibitor concentration at the enzyme active site ([I]) and the in …

Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes

K Ito, K Ogihara, S Kanamitsu, T Itoh - Drug Metabolism and Disposition, 2003 - ASPET
Clinical studies have revealed that plasma concentrations of midazolam after oral administration
are greatly increased by coadministration of erythromycin and clarithromycin, whereas …

[HTML][HTML] Classification of drugs for evaluating drug interaction in drug development and clinical management

K Maeda, A Hisaka, K Ito, Y Ohno, A Ishiguro… - Drug metabolism and …, 2021 - Elsevier
During new drug development, clinical drug interaction studies are carried out in accordance
with the mechanism of potential drug interactions evaluated by in vitro studies. The …

Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm

K Ito, D Hallifax, RS Obach, JB Houston - Drug Metabolism and Disposition, 2005 - ASPET
The success of in vitro derived K i values for predicting drug-drug interactions in vivo has
been mixed. For example, the use of hepatic input concentration of inhibitor has resolved the …