The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human
cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox …

Background: The Wnt/Wingless signalling pathway plays an important role in both embryonic
development and tumorigenesis. β‐Catenin and Axin are positive and negative effectors of …

Prostaglandin E 2 (PGE 2 ) is one of the most typical lipid mediators produced from arachidonic
acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds …

PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes
phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking …

A hallmark of immunopathology associated with Alzheimer’s disease is the presence of
activated microglia (MG) surrounding senile plaque deposition of β-amyloid (Aβ) peptides. Aβ …

Mps one binder 1a (MOB1A) and MOB1B are key components of the Hippo signaling pathway
and are mutated or inactivated in many human cancers. Here we show that intact Mob1a …

PTEN is a tumor suppressor gene mutated in many human cancers. We generated a
bronchioalveolar epithelium–specific null mutation of Pten in mice [SP-C-rtTA/(tetO) 7 -Cre/Pten flox/…

Tamibarotene (Am80), a synthetic retinoid approved in Japan for treatment of acute promyelocytic
leukemia (APL), is a retinoic acid receptor (RAR) agonist with high specificity for RARα …

Although there is a relationship between DNA repair deficiency and temozolomide (TMZ)
resistance in glioblastoma (GBM), it remains unclear which molecule is associated with GBM …

Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a
pivotal role in tumor progression; however, the mechanisms underlying this role are not fully …