To gain insights into the significance of presenilins (PS) in the pathogenetic mechanisms of
early-onset familial Alzheimer disease (FAD), we expressed cDNAs for wild-type PS2 and …

Tetraethylammonium (TEA) induces long-term potentiation (LTP)-like synaptic enhancement
in rat hippocampal slices. To find the genes related to this phenomenon, subtraction …

In some pedigrees of familial Alzheimer's disease (FAD), three mutations of β amyloid
precursor protein (APP) have been found at the Val 717 residue (to Ile, Phe, or Gly) and these …

Clinical reports indicate that cardiotoxicity due to donepezil can occur after coadministration
with cilostazol. We speculated that the concentration of donepezil in heart tissue might be …

Distribution of norbin protein in rats was characterized by immunohistochemical study. It was
distributed not only in whole brain but also in peripheral nervous system. The protein was …

The fate of trafermin (recombinant human basic fibroblast growth factor) was examined after
intravenous administration of its iodinated form to rats. Autoradiography at 5 and 30 min …

We used a mobile electrocardiograph to manage the adverse effects and interactions of drugs,
especially QT-prolonging drugs, in a community pharmacy setting. We report the case of …

A 26-mer peptide of which the sequence contains the presumed pore forming region of the
Shaker K + channel (H5 region) was chemically synthesized. The peptide was found to …

KW8, a NeuroD family basic helix–loop–helix protein, was initially cloned during the course
of screening for the genes related to long term potentiation in rat hippocampal slice. Its …

To preserve germination ability, plant seeds must be protected from environmental stresses
during the storage period. Here, we demonstrate that autophagy, an intracellular …