Exposure of pubertal rats to di-(2-ethylhexyl) phthalate (DEHP) for 14 days was reported to
result in reduced testosterone (T) biosynthesis by altering androstenedione 17β-…

Knowledge of strain differences in drug metabolism is important for the selection of animals
for pharmacokinetic, pharmacodynamic, and toxicological studies. Hepatic microsomes from …

Diazepam was metabolized to three primary metabolites, 3-hydroxy-diazepam, N-desmethyl-diazepam,
and p-hydroxy-diazepam. Our previous studies reported metabolic position-…

We observed variations in the metabolism of diazepam in Wistar rats. We studied these
variations carefully, and found that the variations are dimorphic and about 17% of male rats of …

Diazepam (7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) is widely
used as a sedative, hypnotic, and anti-anxiety drug. At low diazepam concentrations, p-…

Previously, we have reported drastic strain differences of diazepam metabolism in the livers
of a variety of rat strain. In this study, to characterize strain and sex differences of diazepam …

Diazepam was metabolized to three primary metabolites, 3-hydroxy-diazepam, N-desmethyl-diazepam
and p-hydroxy-diazepam. Our previous studies reported metabolic position …

The strain differences in the metabolism of diazepam were examined by using liver
microsomes from 9 weeks-old Wistar and Dark-Agouti (DA) rats of both sexes. Liver microsomal …

The strain differences in the metabolism of diazepam were examined by using liver
microsomes from 9 weeks-old Wistar and Dark-Agouti (DA) rats of both sexes. Liver microsomal …

This paper describes the fabrication of novel MEMS-structured tactile display device with
SMA thick film actuator array (5×5) bonded to an Si substrate with through-substrate via (TSV) …