A soluble guanylate cyclase activator inhibits the progression of diabetic nephropathy in the ZSF1 rat

…, H Wang, X Zhang, K Gueneva-Boucheva… - … of Pharmacology and …, 2016 - ASPET
Therapies that restore renal cGMP levels are hypothesized to slow the progression of
diabetic nephropathy. We investigated the effect of BI 703704, a soluble guanylate cyclase (sGC) …

The novel, clinical-stage soluble guanylate cyclase activator BI 685509 protects from disease progression in models of renal injury and disease

…, H Wang, D Fowler, K Gueneva-Boucheva… - … of Pharmacology and …, 2023 - ASPET
Activation of soluble guanylate cyclase (sGC) to restore cyclic guanosine monophosphate (cGMP)
and improve functionality of nitric oxide (NO) pathways impaired by oxidative stress is …

Determination of hydroxyproline in plasma and tissue using electrospray mass spectrometry

E Kindt, K Gueneva-Boucheva, MD Rekhter… - … of pharmaceutical and …, 2003 - Elsevier
A simple and highly specific method that was developed for the determination of hydroxyproline
in biological samples is described. This method could potentially be used for monitoring …

Selectivity of BI 689648, a novel, highly selective aldosterone synthase inhibitor: comparison with FAD286 and LCI699 in nonhuman primates

SM Weldon, MA Cerny, K Gueneva-Boucheva… - … of Pharmacology and …, 2016 - ASPET
The mineralocorticoid aldosterone is an important regulator of blood pressure, volume, and
electrolyte balance. However, excess aldosterone can be deleterious as a driver of vascular …

An adapted consensus protein design strategy for identifying globally optimal biotherapeutics

…, A Datar, A Kronkaitis, K Gueneva-Boucheva… - Mabs, 2022 - Taylor & Francis
Biotherapeutic optimization, whether to improve general properties or to engineer specific
attributes, is a time-consuming process with uncertain outcomes. Conversely, Consensus …

The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs

…, EL Reyner, JN Bauman, K Gueneva-Boucheva… - Drug metabolism and …, 2002 - ASPET
Bergamottin, a furanocoumarin isolated from grapefruit juice, was investigated for the ability
to increase diazepam bioavailability and for its effect on cytochrome P450 (P450) enzymes …

Quantitative method for biomarkers of collagen degradation using liquid chromatography tandem mass spectrometry

E Kindt, DT Rossi, K Gueneva-Boucheva… - Analytical Biochemistry, 2000 - Elsevier
Preclinical efficacy testing commonly involves studies that require considerable resources
and time. One valuable tool in this endeavor is the characterization of relevant biomarkers. A …

The aldosterone synthase inhibitor FAD286 is suitable for lowering aldosterone levels in ZDF rats but not in db/db mice

…, SM Weldon, KK Gueneva-Boucheva… - Hormone and …, 2017 - thieme-connect.com
Inhibition of aldosterone synthase is an alternative treatment option to mineralocorticoid
receptor antagonism to prevent harmful aldosterone actions. FAD286 is one of the best …

Effect of the ADCC-Modulating Mutations and the Selection of Human IgG Isotypes on Physicochemical Properties of Fc

…, M Crames, Y Wei, D Liu, K Gueneva-Boucheva… - Journal of …, 2022 - Elsevier
Monoclonal antibodies, particularly IgGs and Ig-based molecules, are a well-established
and growing class of biotherapeutic drugs. In order to improve efficacy, potency and …

Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists

…, C Mao, BN Cook, K Gueneva-Boucheva… - Bioorganic & Medicinal …, 2014 - Elsevier
The discovery of a new series of selective S1P 1 agonists is described. This series of
piperazinyl-oxadiazole derivatives was rapidly optimized starting from high-throughput screening …