Glucocorticoids act synergistically with polycyclic aromatic hydrocarbons in increasing mRNA
and protein levels of CYP1A1 in rat liver. The action of dexamethasone to modify CYP1A1 …

Dehydroepiandrosterone (DHEA), the major precursor of androgens and estrogens, has
several beneficial effects on the immune system, on memory function, and in modulating the …

The widely prescribed lipid-lowering statins are considered to be relatively safe drugs.
However, the risk of severe myopathy and drug interactions as a consequence of statin therapy …

The optical spectroscopic characterization of γ‐turns in solution is uncertain and their distinction
from β‐turns is often difficult. This work reports systematic ECD and vibrational circular …

The metabolic fate of deramciclane [(1R,2S,4R)-(–)-2-phenyl-2-(2′-dimethylamino-ethoxy)-1,7,7-trimethyl-bicyclo[2.2.1]heptane],
a new anxiolytic drug candidate, has been …

Background We investigated in postmenopausal women with primary breast cancer prior to
surgical intervention whether, serum levels of different steroid hormones and hormonal …

Simple Summary Adequate histological diagnosis defines the treatment in gynaecologic
oncology. Although transvaginal ultrasound (TVUS) has widespread use in the diagnosis of …

The aim of our study was to identify the form(s) of cytochrome P450 responsible for the
metabolism of deramciclane, a new anxiolytic drug candidate. The main routes of …

Nowadays cardiovascular diseases are among the major causes of mortality in the
developed world. High cholesterol level in blood and atherosclerosis play the main role in …

Cytochrome P450 (P450) enzymes play a central role in biotransformation and elimination
of various xenobiotics (drugs, pesticides, food additives and chemical pollutants). P450 …