SLITHER: a web server for generating contiguous conformations of substrate molecules entering into deep active sites of proteins or migrating through channels in …
PH Lee, KL Kuo, PY Chu, EM Liu… - Nucleic acids research, 2009 - academic.oup.com
Many proteins use a long channel to guide the substrate or ligand molecules into the well-defined
active sites for catalytic reactions or for switching molecular states. In addition, …
active sites for catalytic reactions or for switching molecular states. In addition, …
Intensive anti-inflammatory therapy with dexamethasone in patients with non-small cell lung cancer: effect on chemotherapy toxicity and efficacy
M Leggas, KL Kuo, F Robert, G Cloud… - Cancer chemotherapy …, 2009 - Springer
Background Our preclinical and clinical data suggest that pretreatment with dexamethasone
4 days prior to chemotherapy increased the efficacy and decreased the toxicity of …
4 days prior to chemotherapy increased the efficacy and decreased the toxicity of …
[HTML][HTML] Localization and Functional Characterization of the Rat Oatp4c1 Transporter in an In Vitro Cell System and Rat Tissues
KL Kuo, H Zhu, PJ McNamara, M Leggas - PloS one, 2012 - journals.plos.org
The organic anion transporting polypeptide 4c1 (Oatp4c1) was previously identified as a
novel uptake transporter predominantly expressed at the basolateral membrane in the rat …
novel uptake transporter predominantly expressed at the basolateral membrane in the rat …
The effect of breast cancer resistance protein, multidrug resistant protein 1, and organic anion-transporting polypeptide 1B3 on the antitumor efficacy of the lipophilic …
E Tsakalozou, ED Adane, KL Kuo, A Daily… - Drug Metabolism and …, 2013 - ASPET
AR-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin) is a lipophilic camptothecin analog,
currently under early stage clinical trials. Transporters are known to have an impact on the …
currently under early stage clinical trials. Transporters are known to have an impact on the …
[BOOK][B] Localization and functional characterization of Oatp4c1 transporter in in vitro cell systems and human/rat tissues
KL Kuo - 2012 - search.proquest.com
The organic anion transporting polypeptide 4c1 (Oatp4c1) was previously identified as a
novel uptake transporter predominantly expressed at the basolateral membrane in the rat …
novel uptake transporter predominantly expressed at the basolateral membrane in the rat …
544. Pharmacokinetic Profile of Ibalizumab From a Phase 3 Trial
…, Z Cohen, C Marsolais, KL Kuo… - Open Forum …, 2018 - academic.oup.com
Background Ibalizumab (IBA) is a long-acting humanized monoclonal antibody that binds
domain 2 of the CD4 receptor and blocks HIV-1 infection of host cells. TMB-301 was a 24-week…
domain 2 of the CD4 receptor and blocks HIV-1 infection of host cells. TMB-301 was a 24-week…
Abstract C216: Small molecule antitubulin drugs that evade multiple drug resistance mechanisms.
M Leggas, E Tsakalozou, T Ahmed, KL Kuo… - Molecular Cancer …, 2011 - AACR
Background: A new library of small molecules with structural features resembling combretastatin
analogs was synthesized and two analogues were chosen by the NCI for screening. …
analogs was synthesized and two analogues were chosen by the NCI for screening. …
Validation of the histological localization and subcellular polarity of the Oatp4c1 transporter in the rat kidney
KL Kuo, P McNamara, M Leggas - 2011 - Wiley Online Library
Recently, the organic anion transporting polypeptide 4c1 (4c1) was identified as a novel
uptake transporter predominantly expressed on the basolateral membrane of rat kidney …
uptake transporter predominantly expressed on the basolateral membrane of rat kidney …
The Effect of BCRP, MDR1 and OATP1B3 on the Antitumor Efficacy of the Lipophilic Camptothecin AR-67 In Vitro
E Tsakalozou, ED Adane, KL Kuo, A Daily… - Drug Metabolism and …, 2013 - ASPET
AR-67 is a lipophilic camptothecin analogue, currently under early stage clinical trials.
Transporters are known to have an impact on the disposition of camptothecins and on the …
Transporters are known to have an impact on the disposition of camptothecins and on the …
[PDF][PDF] Intramuscular Ibalizumab: pharmacokinetics, safety and efficacy vs IV Administration
…, SSJ Lee, NC Wang, Y Lai, KWS Kuo… - … on Retroviruses and …, 2017 - croiconference.org
… Hsi-Hsun Lin1, Susan Shin-Jung Lee2, Ning-Chi Wang3, YingAn Lai4, Kuei-Ling Kuo4,
Steven Weinheimer5, Stanley Lewis5 …
Steven Weinheimer5, Stanley Lewis5 …