Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study

N Boku, S Yamamoto, H Fukuda, K Shirao, T Doi… - The lancet …, 2009 - thelancet.com
Background The best chemotherapy regimen for metastatic gastric cancer is uncertain, but
promising findings have been reported with irinotecan plus cisplatin and S-1 (tegafur, 5-chloro…

[PDF][PDF] Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable …

A Ohtsu, Y Shimada, K Shirao, N Boku… - Journal of clinical …, 2003 - researchgate.net
Purpose: To compare fluorouracil (FU) alone with FU plus cisplatin (FP) and with uracil and
tegafur plus mitomycin (UFTM) for patients with advanced gastric cancer in a prospective, …

Risk factors for lymph node metastasis from intramucosal gastric carcinoma

T Yamao, K Shirao, H Ono, H Kondo… - … Journal of the …, 1996 - Wiley Online Library
BACKGROUND Although regional lymph node metastasis from intramucosal early gastric
carcinoma (EGC) is rare, it is very important to clarify the characteristics of patients having …

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1* 6 and* 28

…, T Hamaguchi, N Yamamoto, K Shirao… - Pharmacogenetics …, 2007 - journals.lww.com
Objectives SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with
UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on UGT1A …

UGT1A1 Haplotypes Associated with Reduced Glucuronidation and Increased Serum Bilirubin in Irinotecan‐administered Japanese Patients with Cancer

…, H Minami, A Ohtsu, K Shirao… - Clinical …, 2004 - Wiley Online Library
Purpose A comprehensive haplotype analysis of UGT1A1 in the Japanese population was
conducted, and the effects of these haplotypes were investigated with respect to UGT1A1‐…

Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population

…, M Katoh, K Sugai, N Minami, K Shirao… - Human …, 2004 - Wiley Online Library
In order to identify single nucleotide polymorphisms (SNPs) and haplotype frequencies of
CYP3A4 in a Japanese population, the distal enhancer and proximal promoter regions, all …

Phase II study of a combination of irinotecan and cisplatin against metastatic gastric cancer

N Boku, A Ohtsu, Y Shimada, K Shirao… - Journal of Clinical …, 1999 - ascopubs.org
PURPOSE: A phase II study of a combination chemotherapy regimen of cisplatin (CDDP)
and irinotecan (CPT-11) was conducted to assess its efficacy and feasibility in patients with …

[HTML][HTML] Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly-differentiated neuroendocrine carcinoma

…, Y Yamada, Y Shimada, H Taniguchi, K Shirao - Gastric cancer, 2011 - Springer
Background Neuroendocrine tumors (NETs) occur in various primary sites, but rarely in the
stomach. NETs are classified into three types, carcinoids, malignant carcinoids and poorly …

Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer

…, NT Okita, K Kato, T Hamaguchi, K Shirao… - Clinical cancer …, 2008 - AACR
Purpose: Expression levels of insulin-like growth factor type 1 receptor (IGF-IR), epidermal
growth factor receptor (EGFR), and HER2 expressions have been linked to clinical outcomes …

Sodium thiosulfate solution spray for relief of irritation caused by Lugol's stain in chromoendoscopy

…, H Ono, T Gotoda, D Saito, K Takahiro, K Shirao… - Gastrointestinal …, 2001 - Elsevier
Background: Mucosal iodine staining is known to improve the endoscopic visualization of
esophageal squamous dysplasia and cancer. However, it often causes mucosal irritation …