Essential fatty acids and the brain: possible health implications

KA Youdim, A Martin, JA Joseph - International journal of developmental …, 2000 - Elsevier
Linoleic and α-linolenic acid are essential for normal cellular function, and act as precursors
for the synthesis of longer chained polyunsaturated fatty acids (PUFAs) such as arachidonic …

Flavonoid permeability across an in situ model of the blood–brain barrier

KA Youdim, MZ Qaiser, DJ Begley… - Free radical biology and …, 2004 - Elsevier
Understanding mechanisms associated with flavonoid neuroprotection is complicated by
the lack of information on their ability to enter the CNS. This study examined naringenin and …

Interaction between flavonoids and the blood–brain barrier: in vitro studies

KA Youdim, MS Dobbie, G Kuhnle… - Journal of …, 2003 - Wiley Online Library
There is considerable current interest in the neuroprotective effects of flavonoids. This study
focuses on the potential for dietary flavonoids, and their known physiologically relevant …

A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects

KA Youdim, JA Joseph - Free Radical Biology and Medicine, 2001 - Elsevier
It is rare to see a day pass in which we are not told through some popular medium that the
population is becoming older. Along with this information comes the “new” revelation that as …

Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults

KA Youdim, J McDonald, W Kalt, JA Joseph - The Journal of nutritional …, 2002 - Elsevier
Although antioxidant systems help control the level of reactive oxygen species they may be
overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress …

Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system

KA Youdim, B Shukitt-Hale, JA Joseph - Free Radical Biology and …, 2004 - Elsevier
Over the past few years there has been an exponential growth in the number of reports
describing the effects of nutritional modulation on aging and age-related diseases. Specific …

Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress

KA Youdim, A Martin, JA Joseph - Free Radical Biology and Medicine, 2000 - Elsevier
The objective of this study was to investigate the ability of endothelial cells (EC) to incorporate
anthocyanins and to examine their potential benefits against various oxidative stressors. …

Effect of thyme oil and thymol dietary supplementation on the antioxidant status and fatty acid composition of the ageing rat brain

KA Youdim, SG Deans - British Journal of Nutrition, 2000 - cambridge.org
The present study measured changes in antioxidant enzyme activity in, and the phospholipid
fatty acid composition of the ageing rat brain and tested whether dietary supplementation …

Dietary flavonoids as potential neuroprotectants

KA Youdim, JPE Spencer, H Schroeter, C Rice-Evans - 2002 - degruyter.com
There is an increasing awareness of the role of certain nutritional components, including
dietary flavonoids found in fruit, vegetables and beverages, in the maintenance of health and …

Fruit polyphenolics and brain aging: nutritional interventions targeting age‐related neuronal and behavioral deficits

RL Galli, B Shukitt‐Hale, KA Youdim… - Annals of the New …, 2002 - Wiley Online Library
Nutritional interventions, in this case, increasing dietary intake of fruits and vegetables, can
retard and even reverse age‐related declines in brain function and in cognitive and motor …