Essential fatty acids and the brain: possible health implications
KA Youdim, A Martin, JA Joseph - International journal of developmental …, 2000 - Elsevier
Linoleic and α-linolenic acid are essential for normal cellular function, and act as precursors
for the synthesis of longer chained polyunsaturated fatty acids (PUFAs) such as arachidonic …
for the synthesis of longer chained polyunsaturated fatty acids (PUFAs) such as arachidonic …
Flavonoid permeability across an in situ model of the blood–brain barrier
KA Youdim, MZ Qaiser, DJ Begley… - Free radical biology and …, 2004 - Elsevier
Understanding mechanisms associated with flavonoid neuroprotection is complicated by
the lack of information on their ability to enter the CNS. This study examined naringenin and …
the lack of information on their ability to enter the CNS. This study examined naringenin and …
Interaction between flavonoids and the blood–brain barrier: in vitro studies
There is considerable current interest in the neuroprotective effects of flavonoids. This study
focuses on the potential for dietary flavonoids, and their known physiologically relevant …
focuses on the potential for dietary flavonoids, and their known physiologically relevant …
A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects
KA Youdim, JA Joseph - Free Radical Biology and Medicine, 2001 - Elsevier
It is rare to see a day pass in which we are not told through some popular medium that the
population is becoming older. Along with this information comes the “new” revelation that as …
population is becoming older. Along with this information comes the “new” revelation that as …
Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults
KA Youdim, J McDonald, W Kalt, JA Joseph - The Journal of nutritional …, 2002 - Elsevier
Although antioxidant systems help control the level of reactive oxygen species they may be
overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress …
overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress …
Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system
KA Youdim, B Shukitt-Hale, JA Joseph - Free Radical Biology and …, 2004 - Elsevier
Over the past few years there has been an exponential growth in the number of reports
describing the effects of nutritional modulation on aging and age-related diseases. Specific …
describing the effects of nutritional modulation on aging and age-related diseases. Specific …
Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress
KA Youdim, A Martin, JA Joseph - Free Radical Biology and Medicine, 2000 - Elsevier
The objective of this study was to investigate the ability of endothelial cells (EC) to incorporate
anthocyanins and to examine their potential benefits against various oxidative stressors. …
anthocyanins and to examine their potential benefits against various oxidative stressors. …
Effect of thyme oil and thymol dietary supplementation on the antioxidant status and fatty acid composition of the ageing rat brain
KA Youdim, SG Deans - British Journal of Nutrition, 2000 - cambridge.org
The present study measured changes in antioxidant enzyme activity in, and the phospholipid
fatty acid composition of the ageing rat brain and tested whether dietary supplementation …
fatty acid composition of the ageing rat brain and tested whether dietary supplementation …
Dietary flavonoids as potential neuroprotectants
KA Youdim, JPE Spencer, H Schroeter, C Rice-Evans - 2002 - degruyter.com
There is an increasing awareness of the role of certain nutritional components, including
dietary flavonoids found in fruit, vegetables and beverages, in the maintenance of health and …
dietary flavonoids found in fruit, vegetables and beverages, in the maintenance of health and …
Fruit polyphenolics and brain aging: nutritional interventions targeting age‐related neuronal and behavioral deficits
RL Galli, B Shukitt‐Hale, KA Youdim… - Annals of the New …, 2002 - Wiley Online Library
Nutritional interventions, in this case, increasing dietary intake of fruits and vegetables, can
retard and even reverse age‐related declines in brain function and in cognitive and motor …
retard and even reverse age‐related declines in brain function and in cognitive and motor …