The brain renin–angiotensin system: location and physiological roles

MJ McKinley, AL Albiston, AM Allen, ML Mathai… - The international journal …, 2003 - Elsevier
Angiotensinogen, the precursor molecule for angiotensins I, II and III, and the enzymes renin,
angiotensin-converting enzyme (ACE), and aminopeptidases A and N may all be …

Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis

MJ McKinley, ML Mathai, RM McAllen… - Journal of …, 2004 - Wiley Online Library
The lamina terminalis, located in the anterior wall of the third ventricle, is comprised of the
subfornical organ, median preoptic nucleus (MnPO) and organum vasculosum of the lamina …

Linoleic acid and the pathogenesis of obesity

SS Naughton, ML Mathai, DH Hryciw… - Prostaglandins & other …, 2016 - Elsevier
The modern Western diet has been consumed in developed English speaking countries for
the last 50 years, and is now gradually being adopted in Eastern and developing countries. …

[PDF][PDF] Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine.

SK Balani, BH Arison, L Mathai, LR Kauffman… - Drug metabolism and …, 1995 - Citeseer
Materials and Methods Chemicals. L-735,524 and its tritiated form were prepared at Merck
Re-search Laboratories. The tritium label was incorporated at the 4-position of the …

Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat …

…, PA Lewandowski, D Cameron-Smith, ML Mathai… - Nutrition research, 2009 - Elsevier
The mechanisms of how tea and epigallocatechin-3-gallate (EGCG) lower body fat are not
completely understood. This study investigated long-term administration of green tea (GT), …

Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance

AP Jayasooriya, ML Mathai… - Proceedings of the …, 2008 - National Acad Sciences
In addition to its role in the storage of fat, adipose tissue acts as an endocrine organ, and it
contains a functional renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE) …

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

…, ML Halls, RJ Summers, ML Mathai… - The FASEB …, 2009 - Wiley Online Library
The hormone relaxin inhibits renal myofibroblast differentiation by interfering with TGF‐β1/
Smad2 signaling. However, the pathways involved in the relaxin‐TGF‐β1/Smad2 interaction …

[PDF][PDF] Cisplatin for cancer therapy and overcoming chemoresistance

R Ranasinghe, ML Mathai, A Zulli - Heliyon, 2022 - cell.com
Cisplatin spearheads the anticancer chemotherapeutics in present-day use although acute
toxicity is its primary impediment factor. Among a plethora of experimental medications, a …

[HTML][HTML] Fatty acid modulation of the endocannabinoid system and the effect on food intake and metabolism

SS Naughton, ML Mathai, DH Hryciw… - International journal of …, 2013 - hindawi.com
Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research
focus in the area of obesity due to the system’s role in food intake and glucose and lipid …

Physiological and pathophysiological influences on thirst

…, MJ Cairns, DA Denton, G Egan, ML Mathai… - Physiology & …, 2004 - Elsevier
… The sheep became grossly hypernatremic (plasma Na concentrations 170–190 mmol/l)
and had to be maintained by an administration of water by gavage every 2–3 days to prevent …