Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases
AP Somlyo, X Wu, LA Walker, AV Somlyo - Reviews of Physiology …, 1999 - Springer
The concept of pharmacomechanical coupling, introduced 30 years ago to account for
physiological mechanisms that can regulate contraction of smooth muscle independently of the …
physiological mechanisms that can regulate contraction of smooth muscle independently of the …
Biologically active quassinoids and their chemistry: potential leads for drug design
…, RW Sindelar, LA Walker… - Current medicinal …, 2005 - ingentaconnect.com
Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from
the plants of Simaroubaceae family. Their synthesis has attracted much attention because of …
the plants of Simaroubaceae family. Their synthesis has attracted much attention because of …
Current status and prospects for cannabidiol preparations as new therapeutic agents
…, S Phillips, MA ElSohly, LA Walker - … : The Journal of Human …, 2016 - Wiley Online Library
States and the federal government are under growing pressure to legalize the use of
cannabis products for medical purposes in the United States. Sixteen states have legalized (or …
cannabis products for medical purposes in the United States. Sixteen states have legalized (or …
[HTML][HTML] Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins
Echinocandins are a new generation of novel antifungal agent that inhibit cell wall β(1,3)-glucan
synthesis and are normally cidal for the human pathogen Candida albicans. Treatment …
synthesis and are normally cidal for the human pathogen Candida albicans. Treatment …
[HTML][HTML] Fungal echinocandin resistance
The echinocandins are the newest class of antifungal agents in the clinical armory. These
secondary metabolites are non-competitive inhibitors of the synthesis of β-(1,3)-glucan, a …
secondary metabolites are non-competitive inhibitors of the synthesis of β-(1,3)-glucan, a …
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
…, S Bonney, S Reithel, M Mittelbronn, LA Walker… - Nature medicine, 2012 - nature.com
Adenosine signaling has been implicated in cardiac adaptation to limited oxygen availability.
In a wide search for adenosine receptor A2b (Adora2b)-elicited cardioadaptive responses, …
In a wide search for adenosine receptor A2b (Adora2b)-elicited cardioadaptive responses, …
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective …
…, AD Catling, DJ Webb, M Sankovic, LA Walker… - The Journal of cell …, 1999 - rupress.org
Urokinase-type plasminogen activator (uPA) activates the mitogen activated protein (MAP)
kinases, extracellular signal-regulated kinase (ERK) 1 and 2, in diverse cell types. In this study…
kinases, extracellular signal-regulated kinase (ERK) 1 and 2, in diverse cell types. In this study…
[PDF][PDF] Conceptual framework for developing resilience metrics for the electricity oil and gas sectors in the United States
…, D Jones, T Corbet, C Hanley, LT Walker - … , nm (united states) …, 2014 - energy.gov
This report has been written for the Department of Energy’s Office of Electricity Delivery and
Energy Reliability to support the Office of Energy Policy and Systems Analysis in their writing …
Energy Reliability to support the Office of Energy Policy and Systems Analysis in their writing …
Elevated Cell Wall Chitin in Candida albicans Confers Echinocandin Resistance In Vivo
…, MD Jacobsen, LA Walker… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Candida albicans cells with increased cell wall chitin have reduced echinocandin susceptibility
in vitro. The aim of this study was to investigate whether C. albicans cells with elevated …
in vitro. The aim of this study was to investigate whether C. albicans cells with elevated …
[HTML][HTML] High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling
…, R O'rourke, KL Jones, MY Jeong, LA Walker… - Nature …, 2015 - nature.com
Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic
factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has …
factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has …