Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models
NHG Holford, LB Sheiner - Clinical pharmacokinetics, 1981 - Springer
It is a major goal of clinical pharmacology to understand the dose-effect relationship in
therapeutics. Much progress towards this goal has been made in the last 2 decades through the …
therapeutics. Much progress towards this goal has been made in the last 2 decades through the …
Learning versus confirming in clinical drug development
LB Sheiner - Clinical Pharmacology & Therapeutics, 1997 - Wiley Online Library
… This, of course, is how a full crossover study could be interpreted, but a less rigorous
design can yield similar results (see Sheiner et … Sheiner 28 3 … Sheiner LB. The …
design can yield similar results (see Sheiner et … Sheiner 28 3 … Sheiner LB. The …
Kinetics of pharmacologic response
NHG Holford, LB Sheiner - Pharmacology & therapeutics, 1982 - Elsevier
… SHEINER 1. INTRODUCTION An important goal in clinical pha … A simple means of doing
so has been proposed by Sheiner et al. (1979) which uses an effect compartment as an …
so has been proposed by Sheiner et al. (1979) which uses an effect compartment as an …
Some suggestions for measuring predictive performance
LB Sheiner, SL Beal - Journal of pharmacokinetics and biopharmaceutics, 1981 - Springer
The performance of a prediction or measurement method is often evaluated by computing
the correlation coefficient and/or the regression of predictions on true (reference) values. …
the correlation coefficient and/or the regression of predictions on true (reference) values. …
Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine
LB Sheiner, DR Stanski, S Vozeh… - Clinical …, 1979 - Wiley Online Library
… Galeazzi R, Benet L, Sheiner LB: Relationship between the pharmacokinetics and
pharmacodynamics of procainamide, CUN PHARMACOL THER 20:278-289, 1976. 9. Gibaldi M, …
pharmacodynamics of procainamide, CUN PHARMACOL THER 20:278-289, 1976. 9. Gibaldi M, …
Estimation of population characteristics of pharmacokinetic parameters from routine clinical data
LB Sheiner, B Rosenberg, VV Marathe - Journal of pharmacokinetics and …, 1977 - Springer
… 4Address correspondence to LBS … The exposition relies heavily on the presentation in Sheiner
et al. (1), … of the independent variables ("missing data") are discussed by Sheiner et al. (1). …
et al. (1), … of the independent variables ("missing data") are discussed by Sheiner et al. (1). …
Evaluation of methods for estimating population pharmacokinetic parameters. I. Michaelis-Menten model: routine clinical pharmacokinetic data
LB Sheiner, SL Beal - Journal of pharmacokinetics and biopharmaceutics, 1980 - Springer
… Sheiner and Beal … Sheiner and Beal … SL Beal and LB Sheiner. NONMEMUsers Guide PartI,
UsersBasic Guide, Division of Clinical Pharmacology, University of California, San Francisco, …
UsersBasic Guide, Division of Clinical Pharmacology, University of California, San Francisco, …
The importance of modeling interoccasion variability in population pharmacokinetic analyses
MO Karlsson, LB Sheiner - Journal of pharmacokinetics and …, 1993 - Springer
Individual pharmacokinetic parameters may change randomly between study occasions.
Analysis of simulated data with NONMEM shows that ignoring such interoccasion variability (…
Analysis of simulated data with NONMEM shows that ignoring such interoccasion variability (…
The usefulness of preoperative laboratory screening
EB Kaplan, LB Sheiner, AJ Boeckmann, MF Roizen… - Jama, 1985 - jamanetwork.com
We assessed the usefulness of routine laboratory screening of preoperative patients.
Computer-readable laboratory, demographic, and discharge diagnostic data were assembled for …
Computer-readable laboratory, demographic, and discharge diagnostic data were assembled for …
Building population pharmacokineticpharmacodynamic models. I. Models for covariate effects
JW Mandema, D Verotta, LB Sheiner - Journal of pharmacokinetics and …, 1992 - Springer
One major task in clinical pharmacology is to determine the pharmacokinetic-pharmacodynamic
(PK-PD) parameters of a drug in a patient population. NONMEM is a program commonly …
(PK-PD) parameters of a drug in a patient population. NONMEM is a program commonly …