Type I protein arginine methyltransferases (PRMTs) catalyze asymmetric dimethylation of
arginines on proteins. Type I PRMTs and their substrates have been implicated in human …

A novel aryl pyrazole series of arginine methyltransferase inhibitors has been identified.
Synthesis of analogues within this series yielded the first potent, selective, small molecule …

High-throughput screening has identified a novel class of inhibitors of the checkpoint kinase
Wee1, which have potential for use in cancer chemotherapy. These inhibitors are based on …

CARM1 is an arginine methyltransferase with diverse histone and non-histone substrates
implicated in the regulation of cellular processes including transcriptional co-activation and …

SMYD3 has been implicated in a range of cancers; however, until now no potent selective
small molecule inhibitors have been available for target validation studies. A novel oxindole …

A key challenge in the development of precision medicine is defining the phenotypic
consequences of pharmacological modulation of specific target macromolecules. To address this …

Let $\mathcal{P}(G)$ be the set of all positive semidefinite matrices whose graph is G, and $\operatorname{msr}(G)$
be the minimum rank of all matrices in $\mathcal{P}(G)$. Upper and …

Cells of the pathogenic yeast Candida albicans accumulate as unbudded singlets at stationary
phase in defined medium at 25 C. When released into fresh medium at 37 C and pH 6.5, …

We study the minimum semidefinite rank of a graph using vector representations of the
graph and of certain subgraphs. We present a sufficient condition for when the vectors …

A short efficient enantioselective synthesis of both (+)- and (−)-saudin, a naturally occurring
hypoglycemic diterpene, is described. This synthesis establishes the absolute configuration …