Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

CD Fisher, AJ Lickteig, LM Augustine… - Drug metabolism and …, 2009 - ASPET
Members of the cytochrome P450 (P450) enzyme families CYP1, CYP2, and CYP3 are
responsible for the metabolism of approximately 75% of all clinically relevant drugs. With the …

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

LM Aleksunes, AL Slitt, JM Maher, LM Augustine… - Toxicology and applied …, 2008 - Elsevier
The transcription factor NFE2-related factor 2 (Nrf2) mediates detoxification and antioxidant
gene transcription following electrophile exposure and oxidative stress. Mice deficient in Nrf2 …

Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats

CD Fisher, AJ Lickteig, LM Augustine… - European journal of …, 2009 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diagnoses ranging
from simple fatty liver (SFL), to non-alcoholic steatohepatitis (NASH). This study aimed to …

[BOOK][B] Sex at the margins: Migration, labour markets and the rescue industry

LM Agustín - 2008 - books.google.com
This groundbreaking book explodes several myths: that selling sex is completely different
from any other kind of work; that migrants who sell sex are passive victims; and that the …

Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2

CD Fisher, LM Augustine, JM Maher, DM Nelson… - Drug Metabolism and …, 2007 - ASPET
Garlic oil (GO) contains several linear sulfur compounds, including diallyl sulfide (DAS),
diallyl disulfide (DADS), and diallyl trisulfide (DATS), that induce drug-metabolizing enzymes …

Xenobiotic and endobiotic transporter mRNA expression in the blood-testis barrier

LM Augustine, RJ Markelewicz, K Boekelheide… - Drug Metabolism and …, 2005 - ASPET
A major function of xenobiotic and endobiotic transporters is to move a wide range of
organic substances across cell membranes. Sertoli cells play an important role in protecting …

Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment

LM Aleksunes, LM Augustine, GL Scheffer… - Toxicology, 2008 - Elsevier
The goal of this study was to identify alterations in mRNA and protein expression of various
xenobiotic transport proteins in mouse kidney during cisplatin-induced acute renal failure. …

Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease

…, CD Fisher, LM Augustine, LM Aleksunes… - Drug metabolism and …, 2007 - ASPET
Efflux transporters are responsible for the excretion of numerous xenobiotics and endobiotics
and thus play an essential role in proper liver and kidney function. Nonalcoholic fatty liver …

Migrants in the mistress's house: Other voices in the" trafficking" debate

LM Agustín - Social politics: international studies in gender, state …, 2005 - muse.jhu.edu
The debate over “prostitution” in Western feminism has been going on for many years, 1 but
recent demographic developments in Europe, notably the increase in migrant women from …

New research directions: The cultural study of commercial sex

LM Agustín - Sexualities, 2005 - journals.sagepub.com
A paradoxical combination of moral revulsion and resigned tolerance has permitted the sex
industry’s uncontrolled development in the underground economy and also impeded …