The disposition of many medications is altered during pregnancy. Due to changes in many
physiological parameters as well as variability in the activity of maternal drug-metabolizing …

Transforming growth factor beta (TGF-β) has an important role in mediating T-cell suppression
in B-cell non-Hodgkin lymphoma (NHL). However, the underlying mechanism responsible …

Purpose: Despite potential clinical benefits, implementation of pharmacogenomics (PGx)
faces many technical and clinical challenges. These challenges can be overcome with a …

Although proinflammatory and chemotactic cytokines can profoundly affect the tumor
microenvironment, and many of them have been shown to have therapeutic efficacy in preclinical …

Lack of remission or early relapse remains a major clinical issue in diffuse large B-cell
lymphoma (DLBCL), with 30% of patients failing standard of care. Although clinical factors and …

… Hodge … PR Marri and LS Hodge contributed equally to this work. … Writing, review, and/or
revision of the manuscript: PR Marri, LS Hodge, MJ Maurer, SL Slager, TM Habermann, BK Link, …

Massively parallel sequencing analyses have revealed a common mutation within the MYD88
gene (MYD88 L265P) occurring at high frequencies in many non-Hodgkin lymphomas (…

While the effect of TGF-β on malignant B cells in non-Hodgkin lymphoma (NHL) has been
previously evaluated, studies to specifically define the role of TGF-β in tumor immunity in B-cell …

Cytokines within the tumor microenvironment play an important role in supporting the growth
and survival of B-cell malignancies. One such cytokine, IL-21, promotes the growth of …

… Total RNA was isolated using Trizol LS reagent (Invitrogen) as per the manufacturer's
instructions, and RNA was reverse transcribed with Superscript III Reverse Transcriptase (…