After a single dose of [ 14 C] acetaminophen (150 mg/kg) was administered orally to bile
duct cannulated mice, 13.9% of the radioactivity was recovered in the bile while 41.2% was …

Devil's Claw (Harpagophytum procumbens), an herbal product being marketed in Canada
as a home remedy for the relief of arthritic disease, was screened for efficacy with standard …

The majority of the biological effects of pertussis toxin (PT) are the result of a toxin-catalyzed
transfer of an adenosine diphosphate-ribose (ADP-ribose) moiety from NAD + to the α-…

The metabolism of the urinary tract analgesic phenazopyridine [2, 6‐diamino‐3‐(phenylazo)pyridine;
PAP] was studied in the urine of humans, rats, mice, and guinea pigs. Urinary …

Pertussis toxin (PTx) in its detoxified form is an important component of both whole cell and
acellular pertussis vaccines (ACVs). For safety reasons, it is imperative to ensure that the …

Oxidation, cleavage and degradation of the imidazole and piperazine rings, O-dealkylation,
and aromatic hydroxylation are the reported pathways of ketoconazole (KC) metabolism. …

A concomitant single dose of ethanol (1 g/kg) protected mice from hepatic injury induced by
acetaminophen (250 mg/kg) as evidenced by the lowering of plasma transaminases. …

Ketoconazole (KC), an orally effective systemic antifungal agent, has been associated with
symptomatic hepatotoxicity with an incidence as low as 1 in 2000. Studies from this …

In vitro studies of the desulfuration of parathion at 37C by hepatic tissue from males and
females of nine mammalian species revealed sex and species variation in initial rates of …

The interaction of 14 C‐acetaminophen, 150 mg/kg (20 μCi/kg), and aspirin, 200 mg/kg po,
was studied in male mice. The radiolabel was rapidly absorbed from the GI tract, achieving …