The worldwide prevalence of chronic hepatitis C virus (HCV) infection is estimated to be
approaching 200 million people 1 . Current therapy relies upon a combination of pegylated …

Efforts to further elucidate structure−activity relationships (SAR) within our previously
disclosed series of β-quaternary amino acid linked l-cis-4,5-methanoprolinenitrile dipeptidyl …

Retinoic acid receptors (RAR), thyroid hormone receptors (TR), peroxisome proliferator
activated receptors (PPARs) and the orphan receptor, LXR, bind preferentially to DNA as …

Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain
cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for …

Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of
motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric …

The ob gene product, leptin, is a signaling factor regulating body weight and energy balance.
ob gene expression in rodents is increased in obesity and is regulated by feeding patterns …

Targeted protein degradation as a therapeutic modality has seen dramatic progress and
massive investment in recent years because of the convergence of two key scientific …

Targeted protein degradation via small-molecule modulation of cereblon offers vast potential
for the development of new therapeutics. Cereblon-binding therapeutics carry the safety …

The medicinal chemistry subgroup of the American Chemical Society’s Green Chemistry
Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on the current state of …

Many patients with multiple myeloma (MM) initially respond to treatment with modern combination
regimens including immunomodulatory agents (lenalidomide and pomalidomide) and …