[HTML][HTML] Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma

…, N Gao, X Tian, Y Fang, J Gao, MZ Cui, XP He, LJ Jia… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The lack of information concerning individual variation in drug-metabolizing enzymes is one
of the most important obstacles for designing personalized medicine approaches for …

Pharmacokinetics of three proton pump inhibitors in Chinese subjects in relation to the CYP2C19 genotype

HL Qiao, YR Hu, X Tian, LJ Jia, N Gao… - European journal of …, 2006 - Springer
Objective Omeprazole, lansoprazole and rabeprazole have been widely used as proton
pump inhibitors (PPIs). They can be metabolized in the liver by CYP2C19, a polymorphic …

[HTML][HTML] Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach

…, YF Zhang, N Gao, X Tian, Y Fang, Q Wen, LJ Jia… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) accompanied by severe liver dysfunction is a serious disease,
which results in altered hepatic clearance. Generally, maintenance doses depend upon …

Correlation of cytochrome P450 oxidoreductase expression with the expression of 10 isoforms of cytochrome P450 in human liver

…, MZ Cui, N Gao, X Tian, J Gao, Q Wen, LJ Jia… - Drug Metabolism and …, 2016 - ASPET
Human cytochrome P450 oxidoreductase (POR) provides electrons for all microsomal
cytochromes P450 (P450s) and plays an indispensable role in drug metabolism catalyzed by this …

Intriguing field-effect-transistor performance of two-dimensional layered and crystalline CrI3

RA Patil, HW Tu, MH Jen, JJ Lin, CC Wu, CC Yang… - Materials Today …, 2020 - Elsevier
There are many candidate materials that can be used as channel materials for the next-generation
field effect transistors (FETs). CrI 3 is one of the particular candidates for application …

Polymorphisms and haplotype analysis of IL-4Rα Q576R and I75V in patients with penicillin allergy

CZ Huang, J Yang, HL Qiao, LJ Jia - European journal of clinical …, 2009 - Springer
Background The interleukin (IL)-4 and IL-4R genes are linked to allergic diseases and atopy
and elevated serum IgE levels closely follow the presentation of penicillin allergy. We have …

[HTML][HTML] Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats

N Gao, B Qi, F Liu, Y Fang, J Zhou, L Jia, H Qiao - PloS one, 2014 - journals.plos.org
Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional
Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 …

HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins

Y Jing, H Qiao, Y Zhang, L Jia, T Xin… - Chinese medical …, 2006 - journals.lww.com
Background Because of the pivotal role of the human leukocyte antigen (HLA) class II
molecules in regulating the immune response and their extensive polymorphism, it is not …

[HTML][HTML] Contribution of baicalin on the plasma protein binding displacement and CYP3A activity inhibition to the pharmacokinetic changes of nifedipine in rats in vivo …

ZY Cheng, X Tian, J Gao, HM Li, LJ Jia, HL Qiao - PLoS One, 2014 - journals.plos.org
Baicalin purified from the root of Radix scutellariae is widely used in clinical practices. This
study aimed to evaluate the effect of baicalin on the pharmacokinetics of nifedipine, a CYP3A …

Concentration-dependent inhibitory effects of baicalin on the metabolism of dextromethorphan, a dual probe of CYP2D and CYP3A, in rats

X Tian, ZY Cheng, J He, LJ Jia, HL Qiao - Chemico-biological interactions, 2013 - Elsevier
Baicalin has been shown to possess many pharmacological effects, including antiviral,
antioxidant, anti-cancer and anti-inflammatory properties. In the current study, we reveal the …