Estradiol‐17β‐D‐glucuronide (E 2 17G), an endogenous metabolite of estradiol, induces a
potent dose‐dependent and reversible inhibition of bile flow in the rat. We analyzed the effect …

Endocytic internalization of the multidrug resistance-associated protein 2 (Mrp2) was previously
suggested to be involved in estradiol-17β-d-glucuronide (E 2 17G)-induced cholestasis. …

Hepatotoxicity is associated with major changes in liver gene expression induced by xenobiotic
exposure. Understanding the underlying mechanisms is critical for its clinical diagnosis …

The molecular basis of perinatal changes occurring in major UDP-glucuronosyltransferase (UGT)
family 1 isoforms and in UGT2B1, a relevant isoform belonging to family 2, was …

Estradiol-17β-d-glucuronide (E 2 -17G) induces a marked but reversible inhibition of bile
flow in the rat together with endocytic retrieval of multidrug resistance-associated protein 2 (…

The effect of the diuretic spironolactone (SL) on expression and function of intestinal P-glycoprotein
(P-gp), as well as its impact on intestinal absorption of digoxin, was explored. Rats …

Dapsone (DDS) is currently used in the treatment of leprosy, malaria and in infections with
Pneumocystis jirovecii and Toxoplasma gondii in AIDS patients. Adverse effects of DDS …

The effect of the cholestatic estrogens ethynylestradiol (EE) and estradiol 17β-d-glucuronide
(E2-17G) on expression and activity of intestinal multidrug resistant-associated protein 2 (…

Estradiol-17β-d-glucuronide (E2-17G) induces an acute but reversible inhibition of bile flow
after its intravenous administration to rats, due in part to the endocytic retrieval of the …

The effect of lactation on UDP-glucuronosyltransferase (UGT) and Glutathione S-transferase
(GST) activities was studied in jejunum from mother rats, 14 (LM14) and 21 (LM21) days …