[HTML][HTML] ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
…, AA Seyhan, RS Tarapore, L Schalop, M Stogniew… - Neoplasia, 2020 - Elsevier
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing
compound TIC10. ONC201 appears to act as a selective antagonist of the G protein …
compound TIC10. ONC201 appears to act as a selective antagonist of the G protein …
[HTML][HTML] Discovery and clinical introduction of first-in-class imipridone ONC201
…, A Lev, M Baumeister, L Zhou, A Lulla, M Stogniew… - Oncotarget, 2016 - ncbi.nlm.nih.gov
ONC201 is the founding member of a novel class of anti-cancer compounds called
imipridones that is currently in Phase II clinical trials in multiple advanced cancers. Since the …
imipridones that is currently in Phase II clinical trials in multiple advanced cancers. Since the …
[PDF][PDF] Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
…, MD Minden, W Houry, H Kantarjian, M Stogniew… - Cancer cell, 2019 - cell.com
The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial protein
quality control by degrading misfolded proteins. Using genetic and chemical approaches, …
quality control by degrading misfolded proteins. Using genetic and chemical approaches, …
Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201
…, PY Wen, K Merdinger, L Schalop, M Stogniew… - Journal of neuro …, 2019 - Springer
… He then received 5 cycles of adjuvant temozolomide (dosed at 150–200 mg/m 2 daily for
5 consecutive days of every 28 day cycle) until radiographic progression was observed on a …
5 consecutive days of every 28 day cycle) until radiographic progression was observed on a …
[HTML][HTML] A Bayesian machine learning approach for drug target identification using diverse data types
…, L Huang, K Gayvert, G Galletti, M Stogniew… - Nature …, 2019 - nature.com
Drug target identification is a crucial step in development, yet is also among the most
complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that …
complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that …
First-in-human clinical trial of oral ONC201 in patients with refractory solid tumors
…, L Zheng, WS El-Deiry, JE Allen, M Stogniew… - Clinical cancer …, 2017 - AACR
Purpose: ONC201 is a small-molecule selective antagonist of the G protein–coupled
receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human …
receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human …
Population pharmacokinetic analysis of anidulafungin, an echinocandin antifungal
…, W Knebel, T Ludden, M Stogniew… - The Journal of …, 2004 - Wiley Online Library
The objective of this analysis was to describe the pharmacokinetic characteristics of
anidulafungin in patients with serious fungal disease based on pharmacokinetic data collected …
anidulafungin in patients with serious fungal disease based on pharmacokinetic data collected …
Anidulafungin does not require dosage adjustment in subjects with varying degrees of hepatic or renal impairment
JA Dowell, M Stogniew, D Krause… - The Journal of Clinical …, 2007 - Wiley Online Library
Two open‐label studies assessed the effects of hepatic and renal impairment on anidulafungin
pharmacokinetics. A single 50‐mg dose was administered intravenously to subjects with …
pharmacokinetics. A single 50‐mg dose was administered intravenously to subjects with …
Biological activity of weekly ONC201 in adult recurrent glioblastoma patients
Background ONC201 is a dopamine receptor D2 (DRD2) antagonist that penetrates the
blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and is …
blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and is …
Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212
Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and
acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under …
acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under …