Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.
FA Fitzpatrick, MA Wynalda - The Journal of biological chemistry, 1983 - europepmc.org
Human albumin catalyzed the in vitro transformation of prostaglandin D2 into three novel
dehydration products identified as 9-deoxy-11-keto-15 alpha-hydroxy-delta-5, 9, 12-prostenoic …
dehydration products identified as 9-deoxy-11-keto-15 alpha-hydroxy-delta-5, 9, 12-prostenoic …
[HTML][HTML] Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry.
FA Fitzpatrick, MD Ennis, ME Baze, MA Wynalda… - Journal of Biological …, 1986 - Elsevier
Certain epoxyeicosatrienoic acids (EETs) that were not cyclooxygenase substrates were
effective cyclooxygenase inhibitors. Both (+/-)-14,15-cis-EET and (+/-)-8,9-cis-EET inhibited …
effective cyclooxygenase inhibitors. Both (+/-)-14,15-cis-EET and (+/-)-8,9-cis-EET inhibited …
Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens
…, MJ Zaya, LC Wienkers, MA Wynalda - Journal of medicinal …, 2003 - ACS Publications
A new and promising group of antibacterial agents, collectively known as the oxazolidinones
and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as …
and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as …
In vitro metabolism of clindamycin in human liver and intestinal microsomes
MA Wynalda, JM Hutzler, MD Koets, T Podoll… - Drug metabolism and …, 2003 - ASPET
Incubations with human liver and gut microsomes revealed that the antibiotic, clindamycin,
is primarily oxidized to form clindamycin sulfoxide. In this report, evidence is presented that …
is primarily oxidized to form clindamycin sulfoxide. In this report, evidence is presented that …
Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes
MA Wynalda, MJ Hauer, LC Wienkers - Drug metabolism and disposition, 2000 - ASPET
In vitro studies were conducted to identify the hepatic enzyme(s) responsible for the oxidative
metabolism of linezolid. In human liver microsomes, linezolid was oxidized to a single …
metabolism of linezolid. In human liver microsomes, linezolid was oxidized to a single …
Albumin stabilizes leukotriene A4.
FA Fitzpatrick, DR Morton, MA Wynalda - Journal of Biological Chemistry, 1982 - ASBMB
Chemical analysis of intact leukotriene A4 showed that vertebrate albumins prolonged its
aqueous half-life. At pH 7.4, leukotriene A4 hydrolyzed by first order reaction kinetics with rate …
aqueous half-life. At pH 7.4, leukotriene A4 hydrolyzed by first order reaction kinetics with rate …
Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes
…, C Allievi, MJ Hauer, MA Wynalda - Drug metabolism and …, 1999 - ASPET
… , IL); [ 14 C]testosterone was obtained from DuPont-NEN (Boston, MA); [ 14 C]para-nitrophenol,
1-… from Gentest (Woburn, MA). All other reagents and solvents were of analytical grade. …
1-… from Gentest (Woburn, MA). All other reagents and solvents were of analytical grade. …
Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen
MA Wynalda, LC Wienkers - Drug metabolism and disposition, 1997 - ASPET
… ↵1 LC Wienkers and MA Wynalda:In vitro metabolism of chlorzoxazone is mediated by
human microsomal CYP1A2 and CYP2E1. Presented at seventh North American ISSX meeting, …
human microsomal CYP1A2 and CYP2E1. Presented at seventh North American ISSX meeting, …
Albumin-lipid interactions: prostaglandin stability as a probe for characterizing binding sites on vertebrate albumins
FA Fitzpatrick, MA Wynalda - Biochemistry, 1981 - ACS Publications
… In view of our recent reportthat albumin alteredthe inherent stability of prostaglandin I2 (Wynalda
& Fitzpatrick, 1980), we examined the possibility that albumin might expose other …
& Fitzpatrick, 1980), we examined the possibility that albumin might expose other …
In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents
FA Fitzpatrick, MA Wynalda - Prostaglandins, 1976 - Elsevier
In vivo effects of orally administered inhibitors on prostaglandin E and F levels were determined
in seven organs of the rat. Ibuprofen showed suppression in most tissues three hours …
in seven organs of the rat. Ibuprofen showed suppression in most tissues three hours …