Catechol‐O‐methyltransferase and Its Inhibitors in Parkinson's Disease
Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of
dopaminergic neurons, with consequent reduction in striatal dopamine levels leading to …
dopaminergic neurons, with consequent reduction in striatal dopamine levels leading to …
Interaction of the novel anticonvulsant, BIA 2‐093, with voltage‐gated sodium channels: comparison with carbamazepine
MJ Bonifacio, RD Sheridan, A Parada, RA Cunha… - …, 2001 - Wiley Online Library
Purpose: BIA 2‐093 [(S)‐(‐)‐10‐acetoxy‐10,11‐dihydro‐5H‐dibenz/b,f/azepine‐5‐carboxamide]
is endowed with an anticonvulsant potency similar to that of carbamazepine (CBZ), but …
is endowed with an anticonvulsant potency similar to that of carbamazepine (CBZ), but …
Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action
…, N Pires, MJ Bonifácio… - Pharmacology …, 2015 - Wiley Online Library
… ESL, on its own, preferentially blocks VGSC in rapidly firing neurons (Bonifacio et al. 2001),
but the in vivo effects of ESL may be limited to its extensive conversion into eslicarbazepine. …
but the in vivo effects of ESL may be limited to its extensive conversion into eslicarbazepine. …
Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase
…, HS Ferreira, L Torrão, MJ Bonifácio… - Journal of medicinal …, 2010 - ACS Publications
Novel nitrocatechol-substituted heterocycles were designed and evaluated for their ability to
inhibit catechol-O-methyltransferase (COMT). Replacement of the pyrazole core of the initial …
inhibit catechol-O-methyltransferase (COMT). Replacement of the pyrazole core of the initial …
Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide
S Hebeisen, N Pires, AI Loureiro, MJ Bonifácio… - …, 2015 - Elsevier
This study aimed at evaluating the effects of eslicarbazepine, carbamazepine (CBZ),
oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of voltage-…
oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of voltage-…
Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects: Prediction of Slow …
…, AI Loureiro, R Pinto, MJ Bonifácio… - Clinical …, 2013 - Springer
Background and Objectives Opicapone is a novel catechol-O-methyltransferase (COMT)
inhibitor. The purpose of this study was to evaluate the tolerability, pharmacokinetics (including …
inhibitor. The purpose of this study was to evaluate the tolerability, pharmacokinetics (including …
Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug
…, M Uebachs, C Schaub, NM Pires, MJ Bonifácio… - Brain, 2015 - academic.oup.com
In human epilepsy, pharmacoresistance to antiepileptic drug therapy is a major problem
affecting a substantial fraction of patients. Many of the currently available antiepileptic drugs …
affecting a substantial fraction of patients. Many of the currently available antiepileptic drugs …
Opicapone: a short lived and very long acting novel catechol‐O‐methyltransferase inhibitor following multiple dose administration in healthy subjects
…, AI Loureiro, R Pinto, MJ Bonifácio… - British journal of …, 2013 - Wiley Online Library
Aims The aim of this study was to assess the tolerability, pharmacokinetics and inhibitory
effect on erythrocyte soluble catechol‐ O ‐methyltransferase ( S ‐ COMT ) activity following …
effect on erythrocyte soluble catechol‐ O ‐methyltransferase ( S ‐ COMT ) activity following …
Pharmacological profile of opicapone, a third‐generation nitrocatechol catechol‐O‐methyl transferase inhibitor, in the rat
MJ Bonifacio, L Torrao, AI Loureiro… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Catechol‐ O ‐methyltransferase ( COMT ) is an important target in
the levodopa treatment of Parkinson's disease; however, the inhibitors available have …
the levodopa treatment of Parkinson's disease; however, the inhibitors available have …
Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application
MJ Bonifácio, M Archer, ML Rodrigues, PM Matias… - Molecular …, 2002 - ASPET
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a ubiquitous enzyme in nature that
plays an important role in the metabolism of catechol neurotransmitters and xenobiotics. In …
plays an important role in the metabolism of catechol neurotransmitters and xenobiotics. In …