Patient assessment of disease activity in rheumatoid arthritis (RA) may be useful in clinical
practice, offering a patient-friendly, location independent, and a time-efficient and cost-…

Joint Species Distribution Modelling (JSDM) is becoming an increasingly popular statistical
method for analysing data in community ecology. Hierarchical Modelling of Species …

Purpose The pan-Class I PI3K inhibitor buparlisib (BKM120) has shown activity in a range
of preclinical cancer models. This first-in-man study was initiated to identify the maximum …

In the Spanish Sierra Nevada near 2900 m altitude, the new 30-m telescope for millimeter
astronomy is now operational. The authors describe the original design features, which …

The objective of this study was to determine the metabolic fate and disposition of the
antitumor camptothecine derivative irinotecan (CPT-11). Ten patients with histological proof of …

9004 Background: Capmatinib is a highly potent and selective MET inhibitor. Previous data
of GEOMETRY mono-1 study showed a clinically meaningful overall response rate (ORR) …

Scenario‐based biodiversity modelling is a powerful approach to evaluate how possible
future socio‐economic developments may affect biodiversity. Here, we evaluated the changes …

Direct Air Capture (DAC) of carbon dioxide (CO 2 ) from ambient air has the potential to combat
climate change. DAC systems capture CO 2 using a sorbent material and compress it for …

In tumours that harbour wild-type p53, p53 protein function is frequently disabled by the
mouse double minute 2 protein (MDM2, or HDM2 in humans). Multiple HDM2 antagonists are …

Purpose: A first-in-human phase I study was conducted to characterize safety, efficacy, and
pharmacokinetic (PK) and pharmacodynamic (PD) properties of lumretuzumab, a humanized …