The UDP glucuronosyltransferases (UGT) are a family of enzymes in which substrates
include drugs, xenobiotics, and products of endogenous catabolism. The main source of most …

The results of a multicentre, randomised, double-blind, placebo controlled, crossover trial of
lamotrigine as add-on therapy in patients with partial seizures poorly controlled by …

Cimetidine has been shown to impair elimination of a number of drugs metabolized by the
hepatic mixed‐function oxidase enzymes. It is uncertain whether this is related to its histamine …

A controlled cross‐over study in 12 Victorian public hospitals was performed to examine the
power of marketing techniques in influencing prescribing. The targeted prescribing …

Objective To assess the quality of antibiotic prescribing by Victorian general practitioners,
and the effectiveness of educational intervention techniques in improving prescribing. Design …

Using hepatic vein catheterization this study has provided the first direct measurement of
morphine hepatic extraction in 8 controls and 8 cirrhotics. The extraction ratio was 0.52 in the …

The recent identification and synthesis of the endecapeptide substance P has renewed
interest in this naturally occurring compound. The original substance P of Euler and Gaddum …

Background: It has been hypothesised, mainly from studies with animal models of liver disease,
that the transport of substrates for metabolic enzymes and their subsequent metabolism …

… A solution of 2-methyl-5-cis-phenyl-5trons-hydroxy-2-azabicyclo[2.2.2]octane7 (0.8 g, 0.004
mol) and 10 ml of propionic anhydride in 20 ml of dry CgHg was refluxed for 96 h. The CeHe …

The pharmacokinetics of the newer 1, 4 benzodiazepine temazepam were evaluated in 16
healthy subjects aged 18–92 years and in 15 cirrhotic patients, to ascertain the effect of …