The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), a recently emerged human coronavirus. COVID-…

SARS-CoV-2 can cause acute respiratory distress and death in some patients 1 . Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …

1 X= BF2; 2 X= BF3; 3 X= B [OH] 2; 4 X= Br; 5 X= Li; 6 X= H by analogy to the procedure of
Kaufmann et al. 3 Ulti-mately, however, this approach is not ideal because it still requires …

In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important
targets for drug discovery. The therapeutic potential of nicotinic agonists depends …

Oxazaborolidinones 3, 25, 32, 42, 49, and 53 can be obtained as single diastereomers by
crystallization-induced asymmetric transformation (AT). Asymmetric memory is maintained in …

The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist
site of the α7 neuronal nicotinic receptor (K i =56nM). SAR investigations determined that …

… Schrimpf …

Background and purpose: The α7 nicotinic acetylcholine receptor (nAChR) has attracted
considerable interest as a target for cognitive enhancement in schizophrenia and Alzheimer's …

Amidine-protected oxazaborolidinones 6 and 7 can be made from Me2NCH= NCH (R")
C02Na and KPhBF/TMSCl. The diastereomers undergo equilibration and asymmetric …

Several N-pyridin-3-yl spirobicyclic diamines, designed as conformationally restricted analogs
of tebanicline (ABT-594), were synthesized as novel ligands for nicotinic acetylcholine …