Scientists and decision makers from all sectors agree that risk assessments should be based
on the best available science. Several years ago, the Health and Environmental Sciences …

Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms
may exist for a single agent along the continuum of the full dose–response curve. It is …

Although many questions remain unanswered, the general principle of the sequence of events
leading to cancer after exposure to genotoxic carcinogens has become increasingly clear…

Using a filter-binding assay based on precipitation of pUC13 plasmid DNA bound to calf-thymus
histones, we have determined the efficiency of formation of DNA-protein crosslink …

… We are grateful for the support andassistance of Ms Julie Foley of the National Institute of
Environmental Health Sciences, Dr Thomas L. Gola'sworthy andMr Otis Lyght of the …

… Limited 2-stage growth modeling of the tumor incidence data supports a mechanism that
is more reliant on cell growth dynamics than mutation rates (Bogdanffy et al., 1999b). The …

An increasing number of chemicals have been identified as being toxic to the nasal mucosa
of rats. While many chemicals exert their effects only after inhalation exposure, others are …

The transition from nonclinical to First-in-Human (FIH) testing is one of the most challenging
steps in drug development. In response to serious outcomes in a recent Phase 1 trial (…

Inhalation exposure of rats and mice to glycol ether acetates and acrylate esters causes
degeneration of the olfactory epithelium but not of the respiratory epithelium. Since these …

Experimental observations and theoretical considerations indicate a dose threshold for most
chemically induced noncancer toxic effects below which the increased risk of toxicity is zero…