Following an impassioned plea from Professor EJ Ariens to curtail the proliferation of'sophisticated
nonsense in pharmacokinetics and clinical pharmacology'arising from the neglect of …

The published literature on mechanism based inhibition (MBI) of CYPs was evaluated with
respect to experimental design, methodology and data analysis. Significant variation was …

Inhibition of human cytochrome P4502D6 (CYP2D6)‐catalysed metabolism can lead to
clinically significant alterations in pharmacokinetics. Since there is evidence that the selective …

… MS/MS) detection. The neutral loss scanning technique that can be performed using LC-MS/MS …
Additionally, other MS/MS scanning algorithms can be employed to detect GSH adducts (…

The cytochrome P450 (P450)-mediated biotransformation of tamoxifen is important in
determining both the clearance of the drug and its conversion to the active metabolite,trans-4-…

… PhD † ; Lennard, Martin S. PhD * ; Tucker, Geoffrey T. PhD * ; Flanagan, Robert J. …
Demographic and drug dosage information was entered into a Microsoft Access database …

GENETIC polymorphism in the oxidative metabolism of debrisoquine 1 is largely responsible
for individual differences in its plasma concentration and antihypertensive effect. Poor …

4-Hydroxylation is an important pathway of tamoxifen metabolism because the product of this
reaction is intrinsically 100 times more potent as an oestrogen receptor antagonist than is …

Methamphetamine (MeAmp) abuse has recently experienced a resurgence and approaches
to the treatment of its addiction similar to those used with cocaine have been considered. …

The metabolism of methylenedioxymethamphetamine (MDMA, “ecstasy”) was examined in
a microsomal preparation of the yeast Saccharomyces cerevisiae expressing human …