The key characteristics (KC) of human carcinogens provide a uniform approach to evaluating
mechanistic evidence in cancer hazard identification. Refinements to the approach were …

Several links exist between the two mechanisms of neuronal degeneration (ie, oxygen radical
production and mitochondrial damage) proposed to have a role in Parkinson's disease. …

Purpose of Review Cannabis exposure during critical windows of development may have
intergenerational physiological consequences disrupting epigenetic programming and marks. …

… The aquifer was described as “gravel mixed with clayey soil” and as “sandy strata.”
Because the disposal occurred in a recharge zone (uplands), there would have been steeper …

methyl-4-phenylpyridine (MPP + ) is the putative toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) and is structurally similar to the herbicide paraquat (PQ ++ ). …

Many nitrosamines are potent carcinogens, with more than 30 listed under California’s
Proposition 65. Recently, nitrosamine contamination of commonly used drugs for treatment of …

The present study examined neurochemical, morphological and functional markers of the
nigrostriatal dopamine system in young, intermediate-aged and old squirrel monkeys. Striking …

While scientific knowledge of the potential health significance of chemical exposures has
grown, experimental methods for predicting the carcinogenicity of environmental agents have …

The role of active oxygen species and lipid peroxidation in the toxic effects of diquat, paraquat
and other bipyridyl herbicides remains controversial. In vitro studies have shown that …

methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its oxidized metabolite 1-methyl-4-phenylpyridine
(MPP + ) produce a rapid depletion of intracellular ATP in isolated rat …