The hormonal regulation of human CYP2C18 and CYP2C19, which are expressed in a male-specific
manner in liver and kidney in a mouse transgenic model, was examined. The …

… Letting bm(xi) be an individual gradient boosted tree model constructed in step m and fm−1(xi)
be an ensemble of m − 1 gradient boosted trees, we can express model fm(xi) as …

Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic
biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and …

Preclinical evaluation of drug candidates in experimental animal models is an essential step
in drug development. Humanized mouse models have emerged as a promising alternative …

… The product ion spectrum of m/z 566 showed a base peak at m/z 432, and two peaks at m/z
474 and m/z 548. The proposed structures of fragment m/z 432 and m/z 474 are shown in …

Testosterone (T) is a sex steroid hormone that often varies seasonally and mediates trade-offs
between territorial aggression and parental care. Prior work has provided key insights into …

Purpose To systematically investigate tissue distribution and gender-specific protein expression
of Cytochrome P450 (Cyps) in five mouse genotypes with a background of Friend virus …

The pig has been used as an important animal model for human studies because of its similarity
in size, physiology and disease development. However, in contrast to the extensive data …

CYP2A13, CYP2B6, and CYP2F1 are neighboring cytochrome P450 genes on human
chromosome 19, and the enzymes that they encode overlap in substrate specificity. A CYP2A13/…

Cytochrome P450 (P450) monooxygenases are capable of catalyzing metabolism of various
endogenous and exogenous compounds, such as bile acids, fatty acids, retinoids, steroids, …