Defining the role of gut bacteria in the metabolism of deleobuvir: in vitro and in vivo studies

M McCabe, RS Sane, M Keith-Luzzi, J Xu, I King… - Drug Metabolism and …, 2015 - ASPET
Deleobuvir is a potent inhibitor of the hepatitis C virus nonstructural protein 5B polymerase.
In humans, deleobuvir underwent extensive reduction to form CD 6168. This metabolite was …

HLM-beads: rapid assessment of nonspecific binding to human liver microsomes using magnetizable beads

T Wang, A Whitcher-Johnstone, M Keith-Luzzi… - Drug Metabolism and …, 2021 - ASPET
In early drug development, drug-drug interaction risk is routinely assessed using human liver
microsomes (HLMs). Nonspecific binding of drugs to HLMs can affect the determination of …

Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases

KJ Luzzi, IC MacDonald, EE Schmidt, N Kerkvliet… - The American journal of …, 1998 - Elsevier
In cancer metastasis, only a small percentage of cells released from a primary tumor successfully
form distant lesions, but it is uncertain at which steps in the process cells are lost. Our …

Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate

…, K Luzzi, EE Schmidt, VL Morris, M Grattan… - Cancer research, 1995 - AACR
Metastasis is an inefficient process; only a few cancer cells are able to form tumors after
being released into the circulation. We studied the fate of cancer cells after injection into the …

Inhibition of angiogenesis in liver metastases by carboxyamidotriazole (CAI)

KJ Luzzi, HJ Varghese, IC MacDonald, EE Schmidt… - Angiogenesis, 1998 - Springer
Carboxyamidotriazole (CAI), an inhibitor of calcium-mediated signal transduction, is a promising
new cytostatic anti-cancer drug which has entered Phase II clinical trials, and for which …

[PDF][PDF] CT, USA (MM, RSS, MKL, JX, IK, AWJ, NJ, DJT, YL)

M McCabe, RS Sane, M Keith-Luzzi, J Xu, I King… - academia.edu
Deleobuvir is a potent inhibitor of the hepatitis C virus NS5B polymerase. In humans, deleobuvir
underwent extensive reduction to form CD 6168. This metabolite was not formed in vitro …

Quantification of metastatic inefficiency in a murine liver model.

KJ Luzzi - 1998 - elibrary.ru
… A suspension of fluorescently-labeled cells and 10$\mu $ m diameter microspheres (providing
a standard against which to compare, subsequently, numbers of cells and …

The first fossil leptofoenine wasp (Hymenoptera, Pteromalidae): A new species of Leptofoenus in Miocene amber from the Dominican Republic

MS Engel - 2009 - kuscholarworks.ku.edu
… and niece of Keith Luzzi, who generously donated the holotype and permitted its study. …
I am grateful to Keith Luzzi for making the specimen described herein available for study and …

A new termite bug in Miocene amber from the Dominican Republic (Hemiptera, Termitaphididae)

MS Engel - 2009 - kuscholarworks.ku.edu
… The author is grateful to Keith Luzzi for making this material available for study and for
permitting its deposition in the Division of Entomology’s research collection, and to two …

A male of the bee genus Agapostemon in Dominican amber (Hymenoptera: Halictidae)

MS Engel, LCV Breitkreuz - 2013 - kuscholarworks.ku.edu
… We are grateful to Keith Luzzi for bringing the present specimen to our attention, and for
permitting its study and deposition at the University of Kansas. Additional thanks are provided to …