Human genome sequencing revealed that only ~ 1.5% of the DNA sequence coded for proteins.
More and more evidence has uncovered that a substantial part of the 98.5% so‐called “…

Background: Sunitinib was approved by the US Food and Drug Administration (FDA) on
January 26, 2006, for the treatment of metastatic renal cell carcinoma (mRCC) and …

The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To
explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed …

The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids
interact with Mrp4 with high affinity. Hepatic Mrp4 levels are low, but increase under …

Paclitaxel (PTX) nanocrystals (200 nm) were produced by crystallization from a solution.
Antitumor efficacy and toxicity were examined through a survival study in a human HT-29 colon …

The objectives of these studies were to investigate and compare solid lipid nanoparticles (SLNs)
of two anthracyclines, idarubicin (IDA) and doxorubicin (DOX), against Pgp-mediated …

As a single agent the ERBB1 inhibitor, gefitinib (Iressa; ZD1839) showed minimal activity
against a panel of 10 pediatric tumor xenografts that do not express the ERBB1 receptor. …

The 4-anilinoquinazoline (4-AQ) derivative gefitinib (Iressa) is an oral epidermal growth factor
receptor tyrosine kinase inhibitor. Oral administration of 4-AQ molecules, such as gefitinib, …

Chemotherapy combined with laser therapy and cryotherapy has improved the ocular salvage
rate for children with bilateral retinoblastoma. However, children with late-stage disease …

The use of probe substrates and combinations of ATP-binding cassette (ABC) transporter
knockout (KO) animals may facilitate the identification of common substrates between …