Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial
…, T Swan, DJ Glass, M El Mouelhi, M Fornaro… - The Lancet …, 2018 - thelancet.com
Background Spinal and bulbar muscular atrophy is an X-linked neuromuscular disease
caused by CAG repeat expansion in the androgen receptor gene. Patients with this disease …
caused by CAG repeat expansion in the androgen receptor gene. Patients with this disease …
Sublobular distribution of transferases and hydrolases associated with glucuronide, sulfate and glutathione conjugation in human liver
M El Mouelhi, FC Kauffman - Hepatology, 1986 - journals.lww.com
Activities of glucuronosyltransferase, sulfotransferase, glutathione S-transferase, β-glucuronidase
and sulfatase were determined in microdissected samples of periportal and pericentral …
and sulfatase were determined in microdissected samples of periportal and pericentral …
Species-dependent enantioselective glucuronidation of three 2-arylpropionic acids. Naproxen, ibuprofen, and benoxaprofen.
M el Mouelhi, HW Ruelius, C Fenselau… - Drug metabolism and …, 1987 - ASPET
The enantioselective glucuronidation of several racemic 2-arylproprionic acids (naproxen,
ibuprofen, and benoxaprofen) was investigated in vitro with immobilized microsomal protein …
ibuprofen, and benoxaprofen) was investigated in vitro with immobilized microsomal protein …
Investigations on 5-HT4 receptor expression and effects of tegaserod on human platelet aggregation in vitro
VL Serebruany, M El Mouelhi… - American journal of …, 2010 - journals.lww.com
A meta-analysis of 29 clinical studies on tegaserod revealed an imbalance of cardiovascular
ischemic events in patients treated with drug versus placebo. Because increased platelet …
ischemic events in patients treated with drug versus placebo. Because increased platelet …
Drug metabolizing enzyme activities in rat liver epithelial cell lines, hepatocytes and bile duct cells
…, R Gebhardt, D Mayer, M El Mouelhi… - Biochemical …, 1991 - Elsevier
… with a rubber policeman in 1 mL 0.1 M Tris/0.25 M sucrose, pH 7.4. Cells were homogenized
with … El Mouelhi M and Kauffman FC, Sublobular distribution of transferases and hydrolases …
with … El Mouelhi M and Kauffman FC, Sublobular distribution of transferases and hydrolases …
Drug development and challenges for neuromuscular clinical trials
M El Mouelhi - Journal of Molecular Neuroscience, 2016 - Springer
Drug development process faces many challenges, including those encountered in clinical
trials for neuromuscular diseases. Drug development is a lengthy and highly costly process. …
trials for neuromuscular diseases. Drug development is a lengthy and highly costly process. …
[PDF][PDF] Hydrolysis of organic sulfates in periportal and pericentral regions of the liver lobule: studies with 4-methylumbelliferyl sulfate in the perfused rat liver.
IM Anundi, FC Kauffman, M el-Mouelhi… - Molecular …, 1986 - Citeseer
The hydrolysis of 4-methylumbelliferyl sulfate by liver sulfatases to free fluorescent 4-methylumbelliferone
and the subsequent formation of the glucuronide conjugate were studied in …
and the subsequent formation of the glucuronide conjugate were studied in …
Stereoselective glucuronidation of (R)-and (S)-naproxen by recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) and its human orthologue
M El Mouelhi, S Beck, KW Bock - Biochemical pharmacology, 1993 - Elsevier
… The incubation was stopped with 20 PL 0.5 M HCI. After precipitation of the protein and …
It was eluted with 0.05 M ammonium acetate/acetonitrile (80:20), adjusted to pH6.0. UV …
It was eluted with 0.05 M ammonium acetate/acetonitrile (80:20), adjusted to pH6.0. UV …
[PDF][PDF] Stereoselective (S)-and (R)-naproxen glucuronosyl transferases of rat liver.
M el Mouelhi, KW Bock - Drug metabolism and disposition, 1991 - Citeseer
Stereoselective glucuronidation of naproxen, one of the 2-aryipro-ionIc acids that are widely
used as anti-inflammatory drugs, was investigated in chromatofocusing fractions of …
used as anti-inflammatory drugs, was investigated in chromatofocusing fractions of …
Hepatic cytochrome P-450 system in experimental hepatosplenic schistosomiasis: presence of an artifact in spectrophotometric analysis
M El Mouelhi, M Black, SM Phillips - Biochemical pharmacology, 1987 - Elsevier
Several recent reports suggesting that the liver microsomal cytochrome P-450 system is
impaired in Schistosoma mansoni infections in mice prompted a detailed investigation of the …
impaired in Schistosoma mansoni infections in mice prompted a detailed investigation of the …