Considerations from the IQ induction working group in response to drug-drug interaction guidance from regulatory agencies: focus on downregulation, CYP2C …
…, JR Kenny, H Einolf, M Mohutsky, M Pardon… - Drug Metabolism and …, 2017 - ASPET
The European Medicines Agency (EMA), the Pharmaceutical and Medical Devices Agency (PMDA),
and the Food and Drug Administration (FDA) have issued guidelines for the conduct …
and the Food and Drug Administration (FDA) have issued guidelines for the conduct …
Effect of deuteration on metabolism and clearance of Nerispirdine (HP184) and AVE5638
…, R van Horn, V Czepczor, A Stoltz, M Pardon - Bioorganic & Medicinal …, 2015 - Elsevier
Replacing hydrogen with deuterium as a means of altering ADME properties of drug molecules
has recently enjoyed a renaissance, such that at least two deuterated chemical entities …
has recently enjoyed a renaissance, such that at least two deuterated chemical entities …
Prediction of CYP Down Regulation after Tusamitamab Ravtansine Administration (a DM4‐Conjugate), Based on an In Vitro–In Vivo Extrapolation Approach
…, A Perreard‐Dumaine, M Pardon… - Clinical …, 2024 - Wiley Online Library
Tusamitamab ravtansine is an antibody‐drug conjugate (ADC) composed of a humanized
monoclonal antibody (IgG1) and DM4 payload. Even if DM4 and its main metabolite methyl‐…
monoclonal antibody (IgG1) and DM4 payload. Even if DM4 and its main metabolite methyl‐…
[PDF][PDF] Considerations from the IQ Induction working group in response to drug-drug interaction guidances from regulatory agencies
…, H Einolf, M Mohutsky, M Pardon… - Drug Metabolism and …, 2019 - researchgate.net
The European Medicines Agency (EMA), the Pharmaceutical and Medical Devices Agency (PMDA)
and the Food and Drug Administration (FDA) have issued guidances for the conduct …
and the Food and Drug Administration (FDA) have issued guidances for the conduct …
Un nouveau cachet à collyres découvert à Reims/Durocortorum
M Pardon-Labonnelie, M Cavé, A Troublard - Gallia, 2022 - JSTOR
Un nouveau cachet à collyres, découvert lors de la fouille du complexe aqualudique de
Reims en 2018, présente des caractéristiques morphologiques et épigraphiques …
Reims en 2018, présente des caractéristiques morphologiques et épigraphiques …
Amélioration de la prédiction de la clairance métabolique via l'utilisation de modèles hépatiques innovants
F Da Silva - 2018 - theses.hal.science
La sélection des meilleurs candidats médicament se base sur des choix multiparamétriques
réunissant l’efficacité potentielle, les caractéristiques ADME et le profil de sécurité des …
réunissant l’efficacité potentielle, les caractéristiques ADME et le profil de sécurité des …
Sotrovimab therapy elicits antiviral activities against Omicron BQ. 1.1 and XBB. 1.5 in sera of immunocompromised patients
…, C Salanoubat, A Chabrol, P Housset, A Pardon… - Med, 2023 - cell.com
Antibodies effective against the recent Omicron sublineages are missing. By taking advantage
of a multi-centric prospective cohort of immunocompromised individuals treated for mild-to…
of a multi-centric prospective cohort of immunocompromised individuals treated for mild-to…
Nanobodies as structural probes to investigate the mechanism of fibril formation by the amyloidogenic variants of human lysozyme
J Dumont, E Pardon, M Aumont-Nicaise… - Amyloid Fibrils, Prions …, 2011 - orbi.uliege.be
Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and
double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic …
double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic …
Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients
…, A Pillet, A Lacraz, A Moinat, A Massoumi, A Pardon… - Kidney international, 2020 - Elsevier
The aim of this study was to estimate the incidence of COVID-19 disease in the French
national population of dialysis patients, their course of illness and to identify the risk factors …
national population of dialysis patients, their course of illness and to identify the risk factors …
[BOOK][B] 79-1| 2022 Reims antique, capitale de province
M Cavé - 2022 - journals.openedition.org
Ce dossier réunit 21 études portant sur la ville antique de Reims et relevant de disciplines
et de domaines de recherche variés. Outre la présentation attendue des résultats des …
et de domaines de recherche variés. Outre la présentation attendue des résultats des …